Korean J Pediatr.  2004 Dec;47(12):1300-1305.

Prevalence of Antibodies against Adenoviruses in Korean Children and Adults

• Jang HO
• Lee JA
• Kim NH
• Chung EH
• Lee HJ

Abstract

PURPOSE
Adenoviruses(Ads) are responsible for approximately 10 percent of lower respiratory tract infections(LRTIs) in children. The purpose of this study is to evaluate the prevalence of antibodies (Abs) against common serotypes of Ads in Korean children and adults.
METHODS
The sera were tested for neutralizing Abs against Ad serotypes 1 through 7 and 21 with a colorimetric microneutralization assay employing A549 cells. Sera that neutralized 100 TCID50 of specific types of Ad at 1 : 10 dilution were considered positive.
RESULTS
Two hundred and thirty seven sera(155 children, 82 adults) were tested. Generally, Ab prevalences were high in infants under 6 months of age, decreased in 6-12 months of age and then increased gradually thereafter. By 4-7 years of age, more than 70 percent of children had Abs against Ad types 1-5 and more than 50 percent had Abs against type 6, and the prevalences of Abs in adults against these types were more than 70 percent. Only against types 7 and 21, Abs were found in less than one quarters of the children. Ab prevalence for Ad 7 was less than 50 percent by 35 years and then jumped to 80 percent, which presumably reflects previous outbreaks of Ad 7 more than 30 years ago. Ab prevalence against type 21 was less than 50 percent throughout adulthood.
CONCLUSION
An age-specific increase in antibody prevalence was observed to the common Ads in Korea. We expect these data to be the basis to determine the ages and serotypes of future Ads vaccines by defining the prevalence of neutralizing antibodies to the common Ads.

Keyword

Adenovirus; Antibody; Epidemiology

MeSH Terms

Adenoviridae*
Adult*
Antibodies*
Antibodies, Neutralizing
Child*
Disease Outbreaks
Epidemiology
Humans
Infant
Korea
Prevalence*
Respiratory System
Vaccines
Antibodies
Antibodies, Neutralizing
Vaccines