Clin Exp Otorhinolaryngol.  2013 Jun;6(2):63-67.

Short Term Effects of Repetitive Transcranial Magnetic Stimulation in Patients with Catastrophic Intractable Tinnitus: Preliminary Report

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Seoul, Korea. pmsuh@naver.com
  • 2Department of Otorhinolaryngology, Eulji University Hospital, Eulji University, Daejeon, Korea.
  • 3Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
The short-term effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in the patients with catastrophic and intractable tinnitus were investigated.
METHODS
Fifteen participants were recruited among patients with catastrophic intractable tinnitus to receive 1 Hz rTMS treatment. Tinnitus severity was assessed before rTMS and directly after sham or real rTMS using the tinnitus handicap inventory (THI) and visual analog scale (VAS).
RESULTS
There was no statistical difference in the THI score before and after sham stimulation. However, after 5 replications of real rTMS there was statistically significant reduction in THI score. Eight patients showed a decrease of more than 10 in THI score. Patients who showed a vast change in THI score after rTMS also showed a large decrease in their VAS score (r=0.879, P<0.001). Duration of tinnitus and change of THI score showed statistically significant moderate negative correlation (r=-0.637, P=0.011). But in case of VAS, there was no significant difference between VAS and duration of tinnitus.
CONCLUSION
Among total 15 patients with catastrophic intractable chronic tinnitus, eight patients showed some improvement in symptoms after 1 Hz rTMS. rTMS can be considered management modality for intractable tinnitus even with distress as severe as catastrophic stage.

Keyword

Tinnitus; Transcranial magnetic stimulation

MeSH Terms

Humans
Salicylamides
Tinnitus
Transcranial Magnetic Stimulation
Salicylamides

Reference

1. Jastreboff PJ. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci Res. 1990; 8. 8(4):221–254. PMID: 2175858.
Article
2. Andersson G, Lyttkens L. A meta-analytic review of psychological treatments for tinnitus. Br J Audiol. 1999; 8. 33(4):201–210. PMID: 10509855.
Article
3. Zoger S, Svedlund J, Holgers KM. Relationship between tinnitus severity and psychiatric disorders. Psychosomatics. 2006; Jul-Aug. 47(4):282–288. PMID: 16844885.
Article
4. Arnold W, Bartenstein P, Oestreicher E, Römer W, Schwaiger M. Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: a PET study with [18F]deoxyglucose. ORL J Otorhinolaryngol Relat Spec. 1996; Jul-Aug. 58(4):195–199. PMID: 8883104.
5. Schlee W, Hartmann T, Langguth B, Weisz N. Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neurosci. 2009; 2. 10:11. PMID: 19228390.
Article
6. Lanting CP, de Kleine E, van Dijk P. Neural activity underlying tinnitus generation: results from PET and fMRI. Hear Res. 2009; 9. 255(1-2):1–13. PMID: 19545617.
Article
7. Langguth B, Kleinjung T, Landgrebe M, de Ridder D, Hajak G. rTMS for the treatment of tinnitus: the role of neuronavigation for coil positioning. Neurophysiol Clin. 2010; 3. 40(1):45–58. PMID: 20230935.
Article
8. Bohning DE. Introduction and overview of TMS physics. In : George MS, Belmaker R, editors. Transcranial magnetic stimulation in neuropsychiatry. Washington, DC: American Psychiatric Press;2000. p. 13–44.
9. Hoffman RE, Cavus I. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. Am J Psychiatry. 2002; 7. 159(7):1093–1102. PMID: 12091184.
Article
10. Frank G, Kleinjung T, Landgrebe M, Vielsmeier V, Steffenhagen C, Burger J, et al. Left temporal low-frequency rTMS for the treatment of tinnitus: clinical predictors of treatment outcome-a retrospective study. Eur J Neurol. 2010; 7. 17(7):951–956. PMID: 20158510.
11. Langguth B, de Ridder D, Dornhoffer JL, Eichhammer P, Folmer RL, Frank E, et al. Controversy: does repetitive transcranial magnetic stimulation/transcranial direct current stimulation show efficacy in treating tinnitus patients. Brain Stimul. 2008; 7. 1(3):192–205. PMID: 20633385.
12. Dobie RA. A review of randomized clinical trials in tinnitus. Laryngoscope. 1999; 8. 109(8):1202–1211. PMID: 10443820.
Article
13. Jastreboff PJ, Jastreboff MM. Tinnitus retraining therapy: a different view on tinnitus. ORL J Otorhinolaryngol Relat Spec. 2006; 68(1):23–30. PMID: 16514259.
Article
14. Londero A, Peignard P, Malinvaud D, Nicolas-Puel C, Avan P, Bonfils P. Contribution of cognitive and behavioral therapy for patients with tinnitus: implication in anxiety and depression. Ann Otolaryngol Chir Cervicofac. 2004; 12. 121(6):334–345. PMID: 15711472.
15. Moller AR. Pathophysiology of tinnitus. Otolaryngol Clin North Am. 2003; 4. 36(2):249–266. PMID: 12856295.
16. Eggermont JJ. Pathophysiology of tinnitus. Prog Brain Res. 2007; 166:19–35. PMID: 17956768.
Article
17. Piccirillo JF, Garcia KS, Nicklaus J, Pierce K, Burton H, Vlassenko AG, et al. Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus. Arch Otolaryngol Head Neck Surg. 2011; 3. 137(3):221–228. PMID: 21422304.
Article
18. Marcondes RA, Sanchez TG, Kii MA, Ono CR, Buchpiguel CA, Langguth B, et al. Repetitive transcranial magnetic stimulation improve tinnitus in normal hearing patients: a double-blind controlled, clinical and neuroimaging outcome study. Eur J Neurol. 2010; 1. 17(1):38–44. PMID: 19614962.
Article
19. Kleinjung T, Eichhammer P, Langguth B, Jacob P, Marienhagen J, Hajak G, et al. Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus. Otolaryngol Head Neck Surg. 2005; 4. 132(4):566–569. PMID: 15806046.
Article
20. De Ridder D, Verstraeten E, Van der Kelen K, De Mulder G, Sunaert S, Verlooy J, et al. Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression. Otol Neurotol. 2005; 7. 26(4):616–619. PMID: 16015156.
Article
21. Khedr EM, Rothwell JC, El-Atar A. One-year follow up of patients with chronic tinnitus treated with left temporoparietal rTMS. Eur J Neurol. 2009; 3. 16(3):404–408. PMID: 19175380.
Article
22. Langguth B, Eichhammer P, Kreutzer A, Maenner P, Marienhagen J, Kleinjung T, et al. The impact of auditory cortex activity on characterizing and treating patients with chronic tinnitus: first results from a PET study. Acta Otolaryngol Suppl. 2006; 12. (556):84–88. PMID: 17114149.
23. Smits M, Kovacs S, de Ridder D, Peeters RR, van Hecke P, Sunaert S. Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus. Neuroradiology. 2007; 8. 49(8):669–679. PMID: 17404721.
Article
24. Kleinjung T, Steffens T, Sand P, Murthum T, Hajak G, Strutz J, et al. Which tinnitus patients benefit from transcranial magnetic stimulation? Otolaryngol Head Neck Surg. 2007; 10. 137(4):589–595. PMID: 17903575.
Article
25. Londero A, Langguth B, De Ridder D, Bonfils P, Lefaucheur JP. Repetitive transcranial magnetic stimulation (rTMS): a new therapeutic approach in subjective tinnitus? Neurophysiol Clin. 2006; May-Jun. 36(3):145–155. PMID: 17046609.
26. Rossi S, De Capua A, Ulivelli M, Bartalini S, Falzarano V, Filippone G, et al. Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: a randomised, crossover, double blind, placebo controlled study. J Neurol Neurosurg Psychiatry. 2007; 8. 78(8):857–863. PMID: 17314192.
Article
Full Text Links
  • CEO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr