Korean J Otolaryngol-Head Neck Surg.
2002 Aug;45(8):821-824.
A Case of Hemangiopericytoma-like Tumor of Nasal Septum Diagnosed by Immunohistochemical Staining
- Affiliations
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- 1Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Inje University, Busan Paik Hospital, Busan, Korea. heokw96@kornet.net
- 2Department of Pathology, College of Medicine, Inje University, Busan Paik Hospital, Busan, Korea.
Abstract
- Vascular neoplasms are the most common non-epithelial tumors in the nasal and paranasal regions. However, heman-giopericytomas usually occur in the retroperitoneum or in the thigh and are uncommon in the nasal cavity and paranasal sinuses. Nasal hemangiopericytoma-like (HPCL) tumors should be differentiated from typical hemangiopericytomas. HPCL tumors, a distinctive variety of vascular neoplasm, often originate in a paranasal sinus and extend into the nasal cavity secondarily. They occur most commonly in adults in the sixth and seventh decades of life and clinically mimic allergic polyps with symptoms of nasal obstruction and epistaxis. Microscopically, HPCL tumors are composed predominantly of spindle cells and lack nuclear or cytoplasmic pleomorphism, mitotic activity, hemorrhage, or necrosis demonstrating a vascular architecture. We report a rare case of HPCL tumor originating from nasal septum in a 45-year-old man with the following immunohistochemical features: vimentin (+), CD34 (+), S-100 protein (-), desmin (-), factor VIII-related antigen (-), and fuchinophilia on Masson trichrome stain.
