Korean J Obstet Gynecol.  2011 Jun;54(6):322-325. 10.5468/KJOG.2011.54.6.322.

A case of recurrent angiomyofibroblastoma of the vulva

• Lee DH
• Lee JJ
• Koh MW

• KMID: 2274043
• DOI: http://doi.org/10.5468/KJOG.2011.54.6.322

Abstract

Angiomyofibroblastoma is a rare benign soft tissue tumor of female genital tract. It is considered to be slowly growing, of low potency for local recurrence. We recently experienced a recurrent angiomyofibroblastoma of the vulva. So, we report a recurrent case of angiomyofibroblastoma after local excision 8 years ago.

Keyword

Angiomyofibroblastoma; Recurrence

MeSH Terms

Female
Humans
Recurrence
Vulva

Figure

• 

  Fig. 1 About 4.5 × 1.4 cm sized sausage-shaped, elongated solid mass lesion is seen in left vulva. About 7.5 cm sized mass lesion is seen in uterus. About 2.5 and 1 cm sized two hemorrhagic cystic lesions are seen in right adnexa. About 1.5 cm sized crescentic cystic lesion is seen in rigth lateral aspect of urethra.

• 

  Fig. 2 The tumor shows alternating hypercellular and hypocellular areas associated with prominent vascular pattern (H&E, ×40).

• 

  Fig. 3 The tumor cells show bland-looking oval to round epithelioid appearance (H&E, ×100).

• 

  Fig. 4 Immunoreactivities for desmin, estrogen receptor (ER) and progesterone receptor (PR) are evident, however, negative for actin (Immunohistochemistry, ×200). Desmin (A). A-smooth muscle actin (B). ER (C). PR (D).

Reference

1. Fletcher CD, Tsang WY, Fisher C, Lee KC, Chan JK. Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol. 1992. 16:373–382.

2. Park DY, Kim JY, Kim OH, Lee HS, Sol MY, Suh KS, et al. Recurred angiomyofibroblastoma of the vulva: report of a case. Korean J Pathol. 1996. 30:947–950.

3. Saleh MM, Yassin AH, Zaklama MS. Recurrent angiomyofibroblastoma of the vagina: a case report. Eur J Gynaecol Oncol. 2007. 28:324.

4. Banerjee K, Datta Gupta S, Mathur SR. Vaginal angiomyofibroblastoma. Arch Gynecol Obstet. 2004. 270:124–125.

5. Tochika N, Takeshita A, Sonobe H, Matsumoto M, Kobayashi M, Araki K. Angiomyofibroblastoma of the vulva: report of a case. Surg Today. 2001. 31:557–559.

6. Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol. 1983. 7:463–475.

7. Granter SR, Nucci MR, Fletcher CD. Aggressive angiomyxoma: reappraisal of its relationship to angiomyofibroblastoma in a series of 16 cases. Histopathology. 1997. 30:3–10.

8. Sasano H, Date F, Yamamoto H, Nagura H. Angiomyofibroblastoma of the vulva: case report with immunohistochemical, ultrastructural and DNA ploidy studies and a review of the literature. Pathol Int. 1997. 47:647–650.

9. Enzinger FM, Weiss SW. Soft tissue tumor. 1995. 3rd ed. St. Louis: Mosby.