Ann Dermatol.  2009 Aug;21(3):315-318. 10.5021/ad.2009.21.3.315.

A Case of Neonatal Lupus Erythematosus Showing Transient Anemia and Hepatitis

• Kim KR
• Yoon TY

• KMID: 2266301
• DOI: http://doi.org/10.5021/ad.2009.21.3.315

Abstract

Neonatal lupus erythematosus (NLE) is an autoimmune disease that is associated with transplacental passage of maternal autoantibodies that are reactive to SSA/Ro and SSB/La antigens. Cardiac involvement, hematologic abnormality and hepatic disease may occur in the infants suffering with NLE, in addition to the characteristic skin lesions. We report here on a case of NLE in a 4-week-old female infant who was born to an asymptomatic mother, and the baby displayed the characteristic clinical and histological features of cutaneous NLE with transient anemia and hepatitis. Both the infant and mother were positive for anti-SSA/Ro and anti-SSB/La. There have been 18 case reports of NLE in the Korean literature, including 7 case reports in the dermatological field. We describe herein another case of NLE that showed transient anemia and hepatitis, and we also review the case reports of NLE in the Korean literature.

Keyword

Anemia; Anti-SSA/Ro; Anti-SSB/La; Hepatitis; Neonatal lupus erythematosus

MeSH Terms

Anemia
Autoantibodies
Autoimmune Diseases
Female
Hepatitis
Humans
Infant
Lupus Erythematosus, Systemic
Mothers
Skin
Stress, Psychological
Autoantibodies
Lupus Erythematosus, Systemic

Figure

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  Fig. 1 Erythematous and annular plaques on the face.

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  Fig. 2 Slight keratin plugging of the hair follicles, focal hydropic degeneration of the basal layer in the epidermis and a patchy perivascular, periadnexal, and interstitial infiltrate of lymphohistiocytes in the whole dermis (H&E, ×100).

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