Ann Dermatol.  2012 Nov;24(4):482-484. 10.5021/ad.2012.24.4.482.

Induction of Vitiligo-Like Hypopigmentation after Imiquimod Treatment of Extramammary Paget's Disease

• Kwon HH
• Cho KH

• KMID: 2266051
• DOI: http://doi.org/10.5021/ad.2012.24.4.482

Abstract

No abstract available.

MeSH Terms

Aminoquinolines
Hypopigmentation
Paget Disease, Extramammary
Aminoquinolines

Figure

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  Fig. 1 (A) Extramammary Paget's disease lesions around pubic area. (B) Relatively well defined whitish depigmented patches on the imiquimod application sites after 3 months.

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  Fig. 2 The basal layer of epidermis shows no pigmentation (A) at a low magnification view (H&E stain, ×100), and (B) a high magnification view (×400). The basal layer of epidermis shows negative reaction for (C) Fontana-Masson staining (×100).

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  Fig. 3 Melanocytes in the basal layer of epidermis stained by immunohistochemistry methods using (A) HMB-45 (×400) antibody, and (B) 3,4-dihydroxyphenylalanine staining (×400) were rarely observed in the depigmented lesions.

Reference

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