Ann Dermatol.  2013 Aug;25(3):389-390. 10.5021/ad.2013.25.3.389.

Hailey-Hailey Disease Treated with Topical Tacalcitol

• Jeon SY
• Ha SM
• Ko DY
• Song KH
• Kim KH

• KMID: 2265890
• DOI: http://doi.org/10.5021/ad.2013.25.3.389

Abstract

No abstract available.

MeSH Terms

Dihydroxycholecalciferols
Pemphigus, Benign Familial
Dihydroxycholecalciferols

Figure

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  Fig. 1 (A) Clinical photograph of the present case at first visit. (B) Clinical photograph of the present case at one month after topical tacalcitol treatment.

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  Fig. 2 Histopathologic findings of the lesional skin showing intraepidermal clefts with irregular acantholysis giving a 'dilapidated brick wall appearance' (H&E, ×100).

Reference

1. Hailey H, Hailey H. Familial benign chronic pemphigus. Arch Dermatol Syphilol. 1939; 39:679–685.

2. Rajpara SM, King CM. Hailey-Hailey disease responsive to topical calcitriol. Br J Dermatol. 2005; 152:816–817.

3. Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S. 1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro. Br J Dermatol. 1998; 139:897–901.

4. Hu Z, Bonifas JM, Beech J, Bench G, Shigihara T, Ogawa H, et al. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease. Nat Genet. 2000; 24:61–65.

5. Dhitavat J, Fairclough RJ, Hovnanian A, Burge SM. Calcium pumps and keratinocytes: lessons from Darier's disease and Hailey-Hailey disease. Br J Dermatol. 2004; 150:821–828.