Ann Dermatol.  2010 Aug;22(3):330-332. 10.5021/ad.2010.22.3.330.

A Case of Clear Cell Eccrine Porocarcinoma

• Hong YJ
• Oh JE
• Choi YW
• Myung KB
• Choi HY

• KMID: 2265370
• DOI: http://doi.org/10.5021/ad.2010.22.3.330

Abstract

Eccrine porocarcinoma (EP) is a rare malignant tumor arising from the intraepidermal eccrine duct. The tumor cells frequently contain glycogen, but prominent clear cell changes in EP are rarely reported. A 78-year-old woman presented with a slightly pruritic, erythematous, verrucous plaque on her left thigh. Histopathological examination revealed intraepidermal tumor cell nests composed of small basaloid cells and duct-like structures lined by periodic acid-Schiff (PAS)-positive cuticles. Besides the typical findings of EP, clear cell changes were predominantly observed in the tumor cell aggregations. Herein we report a case of the clear cell variant of EP rarely reported in previous literature.

Keyword

Clear cell; Eccrine porocarcinoma; Malignant eccrine poroma

MeSH Terms

Aged
Cell Aggregation
Eccrine Porocarcinoma
Female
Glycogen
Humans
Thigh
Glycogen

Figure

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  Fig. 1 A 2×2 cm sized, erythematous plaque with focal erosions on the left thigh.

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  Fig. 2 (A) The intraepidermal aggregations were composed of small basaloid cells with sharp demarcations. Prominent clear cell changes were also noted within the tumor nests (H&E, ×40). (B) Acrosyringium-like, spiral ductal structures were seen in some aggregations (H&E, ×100).

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  Fig. 3 (A) In addition to atypical tumor cells, numerous clear cells with ample cytoplasm were observed (H&E, ×400). (B) PAS-positive diastase-labile granules were seen in the cytoplasm of clear cells (×400).

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  Fig. 4 (A) Immunoreactivity for EMA showed focal positivity within the tumor cells (×40). (B) Immunoreactivity for CEA was restricted to the border of the ductal structures (×100).

Reference

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