The Changing Trends of the Incidence and Histopathology of the Female Genital Malignancies in Keimyung University Dongsan Medical Center Between 1975 and 1994

Cho, C H; Cha, S D; Lee, T S; Suh, Y U

Abstract

This study was based on all female genital malignancies with the except of trophoblastic disease which reported to the Keimyung University Dongsan medical center between 1975 and 1994. We evaluated the changing trends of the incidence and histopathology of the female genital malignancies by comparing the two time periods (1975~1984, 1985~1994). In the first ten years, 2,172 cases (2.9%) were registered and in the second ten years, 2,306 cases (2.9%) were registered. There were no statistically differences in the general frequencies. In the period from 1975 to 1984, the average frequency of cervical cancer was 93.4%, ovarian cancer followed with 2.4%, uterine corpus with 1.6%, vulvar and vaginal with 1.2%, tubal with 0.1%. In the period from 1985 to 1994, cervical cancer accounted for 86.0% of all cancer cases, ovarian cancer for 6.3%, corpus cancer for 3.6%, vulvar and vaginal for 2.1%, tubal for 0.1%. During the twenty years period, the frequency of cervical cancer decreased and the incidence of corpus and ovarian cancer increased. The most frequent histologic type of the cervical cancer was squamous cell carcinoma, and followed by adenocarcinoma. Adenocarcinoma of the cervix showed a gradual increase in incidence (5.0% in 1975~1984, 8.2% in 1985~1994). According to invasiness of the cervix, the frequency of cervical intraepithelial neoplasm was increased when compairing the second ten years (38.4%) with the first ten years (25.7%). The peak age incidence of cervical cancer was noted between 40~49 years in the first ten years and also noted between 50~59 years in the second ten years. Based on the FIGO staging system for cervical cancer, stage II was most frequent during first ten years and stage I was most frequent during the second 10 years. There were no frequency changes noted in stage III or IV during study period. Ovarian cancer was the second most common malignancy and gradually increased with incidence. The peak age was 6 th` decade during twenty years. According to histologic subtype, an epithelial ovarian tumor was most frequent. Corpus cancer was the third most common malignancy and specially, endometrial cancer. The peak age between 50~59 years during the study period.