Korean J Med.  2006 Dec;71(6):694-698.

A case of primary esophageal T-cell malignant lymphoma

• Han YC
• Kang MJ
• Park JH
• Lee WS
• Sohn CH
• Kim CH
• Joo YD

Abstract

Gastrointestinal tract (GIT) lymphomas usually originate from B-lymphocytes but rarely from T-lymphocytes. The stomach is the most common site for extranodal GIT lymphoma but the esophagus is a rare site. In addition, a primary esophageal T-cell lymphoma is an uncommon disorder. We encountered a case of a primary esophageal T-cell lymphoma in a 60-year-old man, who had swallowing difficulties and multiple ulcers in the upper and lower esophageal mucosa on gastroscopy. Immunohistochemical staining for the biopsy material from the multiple esophageal ulcers tested positive for LCA and CD45RO (pan T-cell marker) and negative for cytokeratin and CD20 reactivity, respectively. No other abnormal lesions were observed on a computed tomography scan of the neck, chest, abdomen and pelvis. After six cycles of combination chemotherapy with cyclophosphamide, adriamycin, vincristin, prednisolone, etoposide and gemcitabine, the multiple esophageal ulcers had completely disappeared suggesting a complete clinical response. We report this case with a review of the relevant literature.

Keyword

Esophagus; T-cell lymphoma

MeSH Terms

Abdomen
B-Lymphocytes
Biopsy
Cyclophosphamide
Deglutition
Doxorubicin
Drug Therapy, Combination
Esophagus
Etoposide
Gastrointestinal Tract
Gastroscopy
Humans
Keratins
Lymphoma*
Lymphoma, T-Cell
Middle Aged
Mucous Membrane
Neck
Pelvis
Prednisolone
Stomach
T-Lymphocytes*
Thorax
Ulcer
Cyclophosphamide
Doxorubicin
Etoposide
Keratins
Prednisolone