Korean J Nephrol.  2002 Jul;21(4):602-609.

The Correlation between Relative Renal Uptake of (99m)Tc-DMSA Renal Scan and Glomerular Filtration Rate in Patients with Reduced Renal Function

• An SJ
• Jung YS
• Jung HC
• Lee SB
• Kwak IS
• Rha HY

Abstract

BACKGROUND: Glomerular filtration rate(GFR) is an important parameter for the evaluation and monitoring of renal function. The aim of this study was to investigate the correlation between the relative 1 hour uptake of (99m)Tc-DMSA renal scan(DMSA- %uptake, TRUR) and GFR which was estimated by (99m)Tc-DTPA, serum creatinine and 24 hour-urinary creatinine excretion.
METHODS
Between January 1998 and March 2001, 65 patients had undergone (99m)Tc-DMSA renal scan, (99m)Tc-DTPA renal scan, serum creatinine and 24 hour-urinary creatinine excretion. Of them, 42 patients had moderately or severely reduced renal function(DTPA-GFR RESULTS
Of 42 patients, 15 were men and 27 were women(mean age 54 years; range 28-80 years). there were significant differences between mean DTPA-GFR and mean TRUR in both groups(14.8+/-4.7 vs 34.9+/-8.4 mL/min/1.73m2, p < 0.05; 8.9+/-3.7 vs 16.3+/-7.4%, p < 0.05). In group A, TRUR(mean+/-S.D. 8.9+/-3.7%) was not significantly correlated with DTPA-GFR(r=0.263, p > 0.05). In group B, TRUR (mean+/-S.D. 16.3+/-7.4%) was significantly correlated with DTPA-GFR(r=0.731, p < 0.01). In both group, serum creatinine, Ccr and C and G Ccr were significantly correlated with TRUR.
CONCLUSION
Although the relative 1 hour uptake of the (99m)Tc-DMSA renal scan, as a method of renal cortical image could not estimate the true GFR, it showed a good correlation with GFR in patients with moderately reduced renal function. (99m)Tc-DMSA renal scan seems to be helpful to evaluate the renal function in patients with moderately reduced renal function.

Keyword

Glomerular filtration rate; (99m)Tc-DMSA renal scan; (99m)Tc-DTPA renal scan

MeSH Terms

Creatinine
Filtration
Glomerular Filtration Rate*
Humans
Male
Creatinine