Korean J Nephrol.
2008 Jul;27(4):508-512.
A Case of Membranoproliferative Glomerulonephritis Associated with Sjogren's Syndrome
- Affiliations
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- 1Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine, Ulsan, Korea. nepholic@yahoo.co.kr
- 2Department of Pathology, Ulsan University Hospital University of Ulsan College of Medicine, Ulsan, Korea.
Abstract
- Sjogrens syndrome is a slowly progressive autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, resulting in the xerostomia and xerophthalmia. In this syndrome, renal involvement includes interstitial nephritis, clinically manifested by hyposthenuria and renal tubular dysfunction with or without acidosis. Glomerulonephritis, however, is a rare finding and there have been few reports of membranous glomerulopathy or membranoproliferative glomerulonephritis (MPGN). We report a 31-year-old female diagnosed as MPGN associated with primary Sjogren's syndrome. She suffered from recurrent epigastric pain, and revealed a moderate proteinuria. Renal biopsy findings were consistent with type I MPGN and thereafter Sjogren's syndrome was diagnosed by further evaluation. She did not meet the criteria to systemic lupus erythematosus or other connective tissue disease. To our knowledge, this is the first report of MPGN associated with Sjogrens syndrome in Korea.
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