Korean J Nephrol.  2011 Jul;30(4):404-408.

Minimal Change Nephrotic Syndrome Developed after Thymectomy in a Patient with Thymoma

• Doh FM
• Jang SJ
• Koo HM
• Kim EJ
• Shin HS
• Han SH
• Kang SW
• Choi KH
• Yoo TH

Abstract

We report a case of patient with malignant thymoma, who developed nephrotic syndrome several years after thymectomy. This 38-year-old man was diagnosed as myasthenia gravis and malignant thymoma and underwent thymectomy in 2004. Tumor resection and systemic chemotherapy were performed after recurrence in pleura in 2006. He also took pyridostigmine to control his symptoms of myasthenia gravis after thymectomy. Four years later, even though there was no evidence of recurrence of thymoma, he developed a nephrotic syndrome and was diagnosed as a minimal change disease on renal biopsy. After pulse therapy with methylprednisolone followed by oral administration of prednisolone therapy, nephrotic syndrome was improved.

Keyword

Thymoma; Thymectomy; Minimal change disease

MeSH Terms

Administration, Oral
Adult
Biopsy
Humans
Methylprednisolone
Myasthenia Gravis
Nephrosis, Lipoid
Nephrotic Syndrome
Pleura
Prednisolone
Pyridostigmine Bromide
Recurrence
Thymectomy
Thymoma
Methylprednisolone
Prednisolone
Pyridostigmine Bromide