Korean J Dermatol.  2006 Aug;44(8):937-941.

Treatment of Molluscum Contagiosum with High Dose Cimetidine Therapy

  • 1Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. chan71@hanmail.net


BACKGROUND: Molluscum contagiosum is often a difficult problem for dermatologists to treat. Cimetidine is a H2 histamine receptor antagonist that has been used mainly to treat peptic ulcer disease. The use of cimetidine in the treatment of molluscum contagiosum has been reported previously using a dose of 40 mg/kg/day, and has the advantage of being painless and easy to administer, especially for recurrent, extensive, facial and eyelid lesions.
The purpose of this study was to evaluate the clinical effects of high dose cimetidine therapy for molluscum contagiosum.
Twenty patients with molluscum contagiosum were treated using high dose cimetidine therapy (14 females, 6 males; age range 2~16 years).
Of the 20 patients who completed the study, 12 patients (60%) showed complete remission, 3 patients (15%) showed partial remission and 5 patients (25%) showed no response. Five out of 8 patients with atopic dermatitis showed complete remission and one showed partial remission. Of the 12 patients without atopic dermatitis, 7 showed complete remission and 2 showed partial remission.
High dose cimetidine therapy is an effective treatment modality for molluscum contagiosum, and has no severe adverse effects.


Cimetidine; High dose therapy; Molluscum contagiosum
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