Korean J Dermatol.  2009 Nov;47(11):1321-1323.

Acute Generalized Exanthematous Pustulosis in a 10-month-old Infant

• Her Y
• Kil MS
• Park JH
• Kim CW
• Kim SS

Abstract

Acute generalized exanthematous pustulosis (AGEP) is an uncommon aseptic pustular eruption that usually follows recent administration of oral or parenteral drugs. Characteristic AGEP features include the sudden onset of fever with widespread erythematous eruption, rapidly progressing to a fine, non-follicular, micropustular rash. The illness usually resolves spontaneously with fever and pustulation clearing within 15 days, sometimes followed by desquamation. Histopathology shows non-follicular spongiotic pustules in the epidermis filled with neutrophils, a mixed perivascular infiltrate of neutrophils and occasional eosinophils with papillary dermal edema. We describe a 10-month-old boy with AGEP secondary to exposure to amoxicillin. This is an uncommon condition in children.

Keyword

Acute generalized exanthematous pustulosis; Drug eruption; Infant

MeSH Terms

Acute Generalized Exanthematous Pustulosis
Amoxicillin
Child
Drug Eruptions
Edema
Eosinophils
Epidermis
Exanthema
Fever
Humans
Infant
Neutrophils
Amoxicillin