Korean J Anesthesiol.  2006 Dec;51(6):733-737. 10.4097/kjae.2006.51.6.733.

The Effects of Lidocaine, Bupivacaine or Combined with Enflurane on the Contraction of Tracheal Smooth Muscle in Guinea Pig

• Kwon OK
• Bae HM

• KMID: 2243610
• DOI: http://doi.org/10.4097/kjae.2006.51.6.733

Abstract

BACKGROUND: The effects of local and inhalation anesthesia on the contraction of the tracheal smooth muscle have been reported. However, when inhalation and local anesthesia are administered simultaneously, their effects on the contraction of the airway smooth muscle are not well known. Therefore, this study evaluated the effects of lidocaine, bupivacaine, with or without enflurane, on the histamine induced tracheal smooth muscle contraction in guinea pigs.
METHODS
Isolated tracheal rings of guinea pigs were suspended in Krebs solution. The contractions were recorded isometrically using a transducer. A contraction was induced by histamine (10(-5) M). Enflurane (1 MAC) was administered for 15 min after administering the histamine. The cumulative dose responses of the lidocaine and bupivacaine (10(-8) M, 10(-7) M, 10(-6) M, 10(-5) M, 10(-4) M, and 10(-3) M), enflurane-lidocaine and enflurane-bupivacaine groups were checked.
RESULTS
The contraction by histamine were inhibited by lidocaine (10(-4) M and 10(-3) M) and bupivacaine (10(-5) M, 10(-4) M and 10(-3) M). In addition, the contractions were inhibited more significantly in the bupivacaine group (10(-7) M, 10(-6) M, 10(-5) M, 10(-4) M and 10(-3) M) after administering enflurane.
CONCLUSIONS
Lidocaine and bupivacaine inhibited the contractions induced by histamine. The contractions by bupivacaine were further inhibited after administering enflurane.

Keyword

bupivacaine; enflurane; lidocaine; trachea

MeSH Terms

Anesthesia, Inhalation
Anesthesia, Local
Animals
Bupivacaine*
Enflurane*
Guinea Pigs*
Guinea*
Histamine
Inhalation
Lidocaine*
Muscle, Smooth*
Trachea
Transducers
Bupivacaine
Enflurane
Histamine
Lidocaine