Korean J Gastroenterol.  2000 Mar;35(3):301-308.

Histopathologic Analysis according to Depth of Invasion in Early Gastric Cancer with Submucosal Invasion

• Hong SK
• Lim CY
• Kang NY
• Choi J
• Song IH
• Kim JW
• Roe IH
• Go JH
• Chung M

Abstract

We determined the possibility of endosocpic mucosal resection in early gastric cancer with submucosal (sm) invasion, especially carcinoma in which the depth of invasion is limited within superficial.
METHODS
We retrospectively reviewed 35 cases of early gastric carcinoma with submucosal invasion resected by subtotal or total gastrectomy from 1994 through 1998. We analyzed several histopathological factors in relation to degree of submucosal invasion through final pathologic reports. Degree of sm invasion was designated as follows: sm1- the depth of invasion was limited within superficial, one third of the sm layer; sm2- the invasion was limited within two third of sm layer; sm3- the invasion was limited within distal one third of sm layer.
RESULTS
On analysis of the degree of carcinoma invasion into the sm layer, the rate of lymph node metastasis in sm1, sm2, sm3, and sm2+3 were 16.7%, 33.3%, 17.6%, and 21.7%, respectively. The rates of lymphatic ducts or vessels permeation in sm1, sm2, sm3, and sm2+3 were 25%, 33.3%, 11.2%, and 17.4%, respectively. The frequencies of poorly differentiated carcinoma in sm1, sm2, sm3, and sm2+3 were 16.7%, 33.3%, 52.9%, and 47.8%, respectively.
CONCLUSIONS
Poorly differentiated carcinoma and lymph node metastasis were observed less often in sm1 than in sm2 and sm3.

Keyword

SM-carcinoma; Grade of depth of invasion; Endoscopic mucosal resetion

MeSH Terms

Gastrectomy
Lymph Nodes
Neoplasm Metastasis
Retrospective Studies
Stomach Neoplasms*