Korean J Anesthesiol.  1996 Oct;31(4):457-461. 10.4097/kjae.1996.31.4.457.

The Effects of Furosemide on the Recovery from Neuromuscular Blockade Induced by Vecuronium

• Lee GS
• Chun SH
• Kim SI
• Lee JS
• Kim SC
• Park W
• Kim SY

• KMID: 2240352
• DOI: http://doi.org/10.4097/kjae.1996.31.4.457

Abstract

BACKGROUND: The interactions between furosemide and muscle relaxants is controversial. In this study, the effects of furosemide on the recovery from neuromuscular blockade induced by vecuronium were investigated in thirty ASA class 1 or 2 adult patients undergoning elective orthopedic surgery under the general aneshtesia with O2-N2O-enflurane.
METHODS
Furosemide was administered intravenously at 20% spontaneous recovery of first twitch height of TOF(T1) under the neuromuscular monitoring using Relaxograph?(Datex Co. Finland) as follows: placebo in control group, 5mg in group 1 and 20mg in group 2. Recovery index(RI) defined as the time from 25% to 75% recovery of T1, urinary output during this period and serum K+ levels at 10% and 75% recovery of T1 were measured.
RESULTS
RI was shortened significantly in group 1 (11.2+/-3.4 min.) and group 2 (14.9+/-2.7 min.) compared with control group (19.3+/-4.0 min.)(P<0.05). The urinary output was significantly greater in the groups received furosemide than that in the control group(P<0.05), but serum K+ levels were not significantly changed after administration of furosemide.
CONCLUSIONS
Furosemide facilitates recovery of neuromuscular blockade induced by vecuronium.

Keyword

Neuromuscular relaxant vecuronium; Neuromuscular function furosemide; Neuromuscular transmission recovery index

MeSH Terms

Adult
Furosemide*
Humans
Neuromuscular Blockade*
Neuromuscular Monitoring
Orthopedics
Vecuronium Bromide*
Furosemide
Vecuronium Bromide