Korean J Dermatol.  1987 Oct;25(5):562-567.

Effect of pH on Physical Properties of Guinea Pig Skin

• Moon KC
• Kim SN
• Kim JI
• Kim CK

Abstract

This study was undertaken to investigate some mechanical properties of the skin with special relatio to pH. The abdomenal skin of guinea pig was prepared and cut into appropriate skin strips(1.5mm*15mm). The pieces of skin strips were then suvject to measurement (stretching and vreaking load) using a rheometer after treatment in various pH vuffers and humectant solutions (lactic acid, PCA, citric acid). The result are summarized as follows ; 1. Treatment of the skin in the extreme acidic (pH3) solution showed significant deformity (swelling and shrinkage in length). 2. The overall measurements after treatment in the humectant solutions were not significantly different from those in standard vuffer solutions. 3. The stretching was maxiaml at pH7 and minimal in the extreme ranges of pH(pH 3 and pH11). 4. The measurement of vreaking load showed minimal value at acidic pH3 and revealed linear increments as pH increased.

Keyword

pH; Skin; guinea pig

MeSH Terms

Abdomen
Animals
Congenital Abnormalities
Guinea Pigs*
Guinea*
Hydrogen-Ion Concentration*
Passive Cutaneous Anaphylaxis
Skin*