Korean J Clin Neurophysiol.  2013 Jun;15(1):34-36. 10.14253/kjcn.2013.15.1.34.

Acyclovir-Induced Encephalopathy in a Patient with Normal Renal Function

• Lee S
• Yoon IG
• Park JJ
• Kim JI
• Lee GH
• Kim JH

• KMID: 2225200
• DOI: http://doi.org/10.14253/kjcn.2013.15.1.34

Abstract

No abstract available.

Keyword

Acyclovir; Normal renal function; Encephalopathy

MeSH Terms

Acyclovir
Humans
Acyclovir

Figure

• 

  Figure 1. EEG findigns. (A) Initial EEG shows generalized theta slowing without epileptiform discharge. (B) Follow-up portable EEG with 8 channels reveals generalized theta to delta waves with low amplitude after the treatment of intravenous acyclovir.

Reference

1.Peces R., de la Torre M., Alcázar R. Acyclovir-associated encephalopathy in haemodialysis. Nephrol Dial Transplant. 1996. 11:752.

2.Revankar SG., Applegate AL., Markovitz DM. Delirium associated with acyclovir treatment in a patient with renal failure. Clin Infect Dis. 1995. 21:435–436.

3.Rashiq S., Briewa L., Mooney M., Giancarlo T., Khatib R., Wilson FM. Distinguishing acyclovir neurotoxicity from encephalomyelitis. J Intern Med. 1993. 234:507–511.

4.Laskin OL., Longstreth JA., Whelton A. Acyclovir kinetics in end-stage renal disease. Clin Pharmacol Ther. 1982. 31:594–601.

5.Hellde´n A., Odar-Cederlof I., Diener P., Barkholt L., Medin C., Svensson JO, et al. High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study. Nephrol Dial Transplant. 2003. 18:1135–1141.

6.Hellde´n A., Lycke J., Vander T., Svensson JO., Odar-Cederlof I., Stahle L. The acyclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during acyclovir and valaciclovir treatment. J Antimicrob Chemother. 2006. 57:945–949.

7.Smith JP., Weller S., Johnson B., Nicotera J., Luther JM., Haas DW. Pharmacokinetics of Acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function. Antimicrob Agents Chemother. 2010. 54:1146–1151.