J Korean Ophthalmol Soc.  2013 Feb;54(2):303-309. 10.3341/jkos.2013.54.2.303.

Analysis of Clinical Effectiveness of Tafluprost by Ocular Pulse Amplitude

Affiliations
  • 1Department of Ophthalmology, Soonchunhyang University College of Medicine, Seoul, Korea. sjha@schmc.ac.kr

Abstract

PURPOSE
To analyze the clinical effectiveness of tafluprost used in the treatment of glaucoma, using ocular pulse amplitude (OPA) measurements with dynamic contour tonometry (DCT).
METHODS
Sixty patients (119 eyes) with normal tension glaucoma (NTG) or primary open angle glaucoma (POAG) treated with tafluprost or other eyedrops were investigated in the present study. Intraocular pressure (IOP) was measured with Goldmann applanation tonometry (GAT), and OPA was measured with DCT, before and after treatment, retrospectively.
RESULTS
In 20 patients treated with tafluprost, IOP decreased from 17.1 mm Hg before treatment to 13.0 mm Hg 3 months after treatment (24.0% descent rate), and OPA decreased from 2.35 to 1.57 (33.2% descent rate). For 20 patients who switched from another monotherapy to tafluprost, IOP decreased from 15.7 mm Hg to 13.2 mm Hg from 15.7 mm Hg (15.3%) and OPA from 2.38 to 1.69 (27.7%).
CONCLUSIONS
Tafluprost used to treat glaucoma has a large OPA and IOP lowering effect and, therefore can be applied to patients who have a large OPA with glaucoma progression in spite of well controlled IOP.

Keyword

Normal tension glaucoma; Ocular pulse amplitude; Primary open angle glaucoma; Tafloprost

MeSH Terms

Glaucoma
Glaucoma, Open-Angle
Humans
Intraocular Pressure
Low Tension Glaucoma
Manometry
Ophthalmic Solutions
Prostaglandins F
Ophthalmic Solutions
Prostaglandins F
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