J Korean Ophthalmol Soc.  2015 Apr;56(4):485-493. 10.3341/jkos.2015.56.4.485.

Comparison of Ganglion Cell-Inner Plexiform Layer and Retinal Nerve Fiber Layer after Cataract Surgery

Affiliations
  • 1Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea. khjinmd@khmc.or.kr

Abstract

PURPOSE
To observe the change in the measured thickness of ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thickness before and after cataract surgery.
METHODS
Forty-six eyes of 32 patients, scheduled to have cataract surgery, were imaged with spectral-domain optical coherence tomography (OCT) (Cirrus HD OCT) before and 5 weeks after the surgery to measure GCIPL and RNFL thickness repeatly.
RESULTS
All GCIPL and RNFL thickness parameters were significantly higher postoperatively compared with preoperative measurements (p < 0.001). RNFL thickness changed more than GCIPL; the increased amount of mean RNFL thickness (14.16%) was higher than GCIPL thickness (7.36%; p < 0.001). GCIPL and RNFL thicknesses and, GCIPL signal strength changes were significantly increased in all types of cataracts (p < 0.05). RNFL signal strength change was significantly increased in posterior subcapsular cataracts (p < 0.05).
CONCLUSIONS
Cataracts may affect GCIPL and RNFL thicknesses. After cataract surgery, GCIPL thickness, similar to the RNFL thickness, was increased significantly. As GCIPL thickness may be less affected by cataracts than RNFL thickness, GCIPL thickness may be a more meaningful indicator for the diagnosis of glaucoma with cataract.

Keyword

Cataract surgery; Ganglion cell-inner plexiform layer; Glaucoma diagnosis; Optical coherence tomography

MeSH Terms

Cataract*
Diagnosis
Ganglion Cysts*
Glaucoma
Humans
Nerve Fibers*
Retinaldehyde*
Tomography, Optical Coherence
Retinaldehyde

Figure

  • Figure 1. Cirrus HD-OCT images of the macula of the right eye. (A) GCIPL thickness maps (the denser the orange/yellow ring, the thicker the GCIPL) (B) Boundary lines drawn to measure GCIPL thickness. The pur-ple line indicates the boundary between the RNFL and GCL. And the yellow line indicates the boundary between the IPL and INL. (C) GCIPL division map. The significance map shows (clockwise) thickness of the superior, superonasal, inferonasal, inferior, inferotemporal, and superotemporal sectors of the annulus and the average and minimum GCIPL (box) (D) GCIPL deviation map. GCIPL = ganglion cell-inner plexiform layer; RNFL = retinal nerve fiber layer; HD-OCT = high definition-OCT; GCL = ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer.

  • Figure 2. GCIPL and RNFL thickness measurement before (A) and after (B) cataract surgery. RNFL thickness measurement before (C) and after (D) cataract surgery. After cataract surgery, both GCIPL and RNFL thickness were increased. GCIPL thickness was less changed than RNFL. GCIPL = ganglion cell-inner plexiform layer; RNFL = retinal nerve fiber layer; GCL = ganglion cell layer; IPL = inner plexiform layer; C/D = cup/disc; N = nasal; S = superior; T = temporal; I = inferior.


Reference

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