J Korean Surg Soc.  2010 Mar;78(3):203-206. 10.4174/jkss.2010.78.3.203.

Splenic Littoral Cell Angioma with Hepatitis C Associated Liver Cirrhosis

Affiliations
  • 1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jrhuh@amc.seoul.kr

Abstract

Littoral cell angioma (LCA) of spleen is an uncommon vascular neoplasm of littoral cell origin. It is well established that LCA may be associated with other malignancy or autoimmune disorders. We describe a 34-year-old woman with viral hepatitis C associated liver cirrhosis who presented with the incidental finding of LCA. She showed ascites, esophageal varix and drowsy mentality. Abdominal computed tomography (CT) showed multiple benign looking nodules in both hepatic lobes, but no abnormality in spleen. Liver transplantation and splenectomy were performed. Microscopic findings revealed narrow anastomosing vascular channels lined with plump cells that exfoliated into the lumen. Immunohistochemically the lining cells were positive for CD31, CD68 and negative for CD34, consistent with LCA. Herein, a second case of an incidentally detected LCA with cirrhosis, viral hepatitis C associated in Korea is reported.

Keyword

Littoral cell angioma; Spleen; Cirrhosis; Hepatitis C

MeSH Terms

Adult
Ascites
Esophageal and Gastric Varices
Female
Fibrosis
Hemangioma
Hepatitis
Hepatitis C
Humans
Incidental Findings
Korea
Liver
Liver Cirrhosis
Liver Transplantation
Spleen
Splenectomy
Splenic Neoplasms
Vascular Neoplasms
Hemangioma
Splenic Neoplasms

Figure

  • Fig. 1 (A) In low power view, well-defined multiple anastomosing vascular channels are observed (H&E stain, ×40). (B) The tumor cells are arranged with pseudopapillary projection and showed bland cytologic characteristics such as somewhat vesicular nuclei and a pale, eosinophilic cytoplasm (H&E stain, ×400).

  • Fig. 2 The tumor shows diffuse immunopositivity for CD31, ×400 (A), CD68, ×400 (B), CD163, ×400 (C), but immunonegativity for CD34, ×400 (D).


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