J Korean Soc Radiol.  2010 Jul;63(1):41-43. 10.3348/jksr.2010.63.1.41.

Prostate Cancer Associated with Mediastinal and Pleural Metastasis: A Case Report

• Lee TK
• Nam JE
• Chang SJ
• Choe KO

• KMID: 2208884
• DOI: http://doi.org/10.3348/jksr.2010.63.1.41

Abstract

Mediastinal and pleural metastasis of prostate cancer is very rare. To our knowledge, there have been no reported cases of prostate cancer associated with mediastinal metastasis and pleural seeding nodules. We report a histopathologically confirmed case of mediastinal and pleural metastasis originating from prostate cancer by biopsy, which on initial diagnosis, was suspected as being a malignant thymic tumor with pleural metastasis.

MeSH Terms

Biopsy
Mediastinum
Neoplasm Metastasis
Prostate
Prostatic Neoplasms
Seeds
Thymus Neoplasms

Figure

• 

  Fig. 1 A. Chest radiograph shows huge bulging mass in the anterior mediastinum. B. The mediastinal setting of the contrast enhanced chest CT scan shows huge lobulated mass with internal necrosis in the anterior mediastinum. C. CT scan obtained below the level of Fig. 1B shows multiple pleural seeding nodules (arrows) along the posterior pleura in bilateral lungs. D. FDG-PET/CT scan shows mild FDG uptake on anterior mediastinal mass. E. The tumor cell is positive immunoreactivity for PSA (stain with brown color).

Reference

1. Park SK, Sakoda LC, Kang D, Chokkalingam AP, Lee E, Shin HR, et al. Rising prostate cancer rates in South Korea. Prostate. 2006; 66:1285–1291.

2. Koutsilieris M. Skeletal metastases in advanced prostate cancer: cell biology and therapy. Crit Rev Oncol Hematol. 1995; 18:51–64.

3. Long MA, Husband JE. Features of unusual metastases from prostate cancer. Br J Radiol. 1999; 72:933–941.

4. Bubendorf L, Schopfer A, Wagner U, Sauter G, Moch H, Willi N, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol. 2000; 31:578–583.

5. Moura FM, Garcia LT, Castro LP, Ferrari TC. Prostate adenocarcinoma manifesting as generalized lymphadenopathy. Urol Oncol. 2006; 24:216–219.

6. McGarry RC. Superior vena cava obstruction due to prostate carcinoma. Urology. 2000; 55:436.

7. Kosugi S, Mizumachi S, Kitajima A, Igarashi T, Hamada T, Kaya H, et al. Prostate cancer with supraclavicular lymphadenopathy and bulky abdominal tumor. Intern Med. 2007; 46:1135–1138.

8. Alanen KA, Kuopio T, Koskinen PJ, Nevalainen TJ. Immunohistochemical labelling for prostate specific antigen in non-prostatic tissues. Pathol Res Pract. 1996; 192:233–237.

9. Effert PJ, Bares R, Handt S, Wolff JM, Bull U, Jakse G. Metabolic imaging of untreated prostate cancer by positron emission tomography with 18fluorine-labeled deoxyglucose. J Urol. 1996; 155:994–998.