J Korean Ophthalmol Soc.  1995 Dec;36(12):2213-2217.

Efficacy of High Dose Corticosteroid Therapy in Experimental Traumatic Optic Neuropathy

Affiliations
  • 1Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea.
  • 2Department of Pathlogy, College of Medicine, Yonsei University, Seoul, Korea.

Abstract

We investigated the efficacy of high dose corticosteroid therapy in the treatment of traumatic optic-neuropathy. We experimentally damaged the optic nerves of six white rabbits with a Hartman mosquito. Three of the rabbits were intravenously injected with 0.25mg/kg dexamethasone every six hours for a 48 hour period. The others were used as controls. In both groups, the optic nerves were removed after one month and stained with Hematoxyline-eosin, then examined microscopically. No histological differences were found in either the control or the experimental group.

Keyword

Corticosteroid therapy; Optic nerve; Traumatic optic-neuropathy

MeSH Terms

Culicidae
Dexamethasone
Optic Nerve
Optic Nerve Injuries*
Rabbits
Dexamethasone
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