J Korean Radiol Soc.  1998 Oct;39(4):763-767. 10.3348/jkrs.1998.39.4.763.

Hepatocellular Carcinoma Localized in the Bile Duct Lumen: Two case report

• Bae KK
• Chang JC

• KMID: 2201227
• DOI: http://doi.org/10.3348/jkrs.1998.39.4.763

Abstract

Intrabile duct tumor growth of hepatocellular carcinoma is an uncommon manifestation, but intraluminal bileduct hepatocellular carcinoma without primary hepatic parenchymal lesions is extremely rare. To our knowledge,only a few case reports have been published. We encountered two cases of primary hepatocellular carcinoma arisingin the bile duct; serum alpha-fetoprotein levels were within the normal limits. Both showed the followingcharacteristic radiologic features: 1) Cholangiography revealed filling defects within the dilated bile duct; 2)two-phase abdominal CT showed enhancement during the arterial-dominant phase and washout during the tissueequilibrium phase, as in typical HCC; and 3) hepatic arteriography revealed hypervascular tumor staining. Surgerywas performed and the resected specimen showed no detectable primary hepatic parenchymal mass; on the basis of thepathologic findings, intraluminal bile duct hepatocellular carcinoma was confirmed. We cautiously assume that thispeculiar type of HCC may arise primarily from bile duct mucosa.

Keyword

Liver neoplasms, CT; Bile ducts, neoplasms

MeSH Terms

alpha-Fetoproteins
Angiography
Bile Ducts*
Bile*
Carcinoma, Hepatocellular*
Cholangiography
Mucous Membrane
Tomography, X-Ray Computed
alpha-Fetoproteins