J Korean Radiol Soc.  1999 Jun;40(6):1113-1117. 10.3348/jkrs.1999.40.6.1113.

Prognostic Factors in Transcatheter Arterial Chemoembolizationc of Hepatocellular Carcinoma: Analysis of Morethan 3 Year Survivors

• Seo HS

• KMID: 2200934
• DOI: http://doi.org/10.3348/jkrs.1999.40.6.1113

Abstract

PURPOSE: To determine which prognostic factors contribute to long-term survival after transcatheter arterialchemoembolization(TACE) of hepatocellular carcinoma.
MATERIALS AND METHODS
In 100 patients who expired withinone year and 84 who survived or have survived for more than 3 years after TACE, prognostic factors wereretrospectively evaluated. TACE was accomplished by hepatic arterial infusion of a suspension of Lipiodol andanticancer drugs(Mitomycin-C and Adriamycin), either alone or followed by gelfoam embolization. Fisher 's exacttest of probability was used to determine which prognostic factors were statistically significant.
RESULTS
Statistically significant prognostic factors were as follows: Child classification(p<0.01), alpha-fetopro-teinvalue(p<0.05), type of tumor(p<0.01), portal vein status(p<0.01), and vascularity of the tumor(p<0.05). HBsAg,tumor size, and method of chemoembolization were not statistically significant(p>0.05).
CONCLUSION
The prognosisof patients with hepatocellular carcinoma treated by TACE was affected favorably by good liver function(Childclassification A), low alphafetoprotein value, nodular or massive-type tumor, patent main and first-order portalvein, and hypervascular tumor.

Keyword

Liver neoplasms, chemotherapeutic infusion; Arteries, therapeutic blockade; Hepatic arteries, chemotherapeuticinfusion

MeSH Terms

Carcinoma, Hepatocellular*
Child
Ethiodized Oil
Gelatin Sponge, Absorbable
Humans
Liver
Portal Vein
Survivors*
Ethiodized Oil