J Lab Med Qual Assur.  2010 Dec;32(2):237-241.

Evaluation of Hemo Techt NS-plus C15 Automatic Analyzer for Fecal Occult Blood Test

• Kim JH
• Hwang SY
• Kim YJ

Abstract

BACKGROUND
Fecal occult blood tests have been widely used for colorectal cancer screening. In recent years, many laboratories have used automated fecal occult blood test analyzers using immunologic techniques for convenience, fast reporting and quantitative handling. Hemo Techt NS-Plus C15 (NS-Plus C) (Alfresa pharma Co., Japan) is a newly-introduced automated fecal occult blood test analyzer using colloidal gold agglutination methods. We evaluated the performance of NS-Plus C.
METHODS
The linearity, precision and carry-over rate of NS-Plus C were evaluated. We performed parallel test between NS-Plus C and HM-JACK (Kyowa Medix Co., Japan) using 219 stool specimens.
RESULTS
The linearity was good (R2=0.998) and coefficient of variation (CVs) of within-day precision were 2.61% and 2.07% in low and high concentration, and between-day CVs for each group were 3.18% and 1.63%, respectively. Carry over rate was 0% and concordance rate between NS-Plus C and HM-JACK was 98.6%.
CONCLUSIONS
NS-Plus C showed good performance for linearity, precision, carry over rate and comparison study. Therefore, this is believed to be a highly reliable measurement system for fecal occult blood test.

Keyword

Fecal occult blood test; Colorectal cancer; NS-plus C

MeSH Terms

Agglutination
Colorectal Neoplasms
Gold Colloid
Handling (Psychology)
Immunologic Techniques
Mass Screening
Occult Blood
Gold Colloid