J Korean Neurosurg Soc.  2015 Jun;57(6):469-472. 10.3340/jkns.2015.57.6.469.

Intracranial Undifferentiated Sarcoma Arising from a Low-Grade Glioma: A Case Report and Literature Review

• Kim BJ
• Kim JH
• Chung HS
• Kwon TH

• KMID: 2191257
• DOI: http://doi.org/10.3340/jkns.2015.57.6.469

Abstract

Undifferentiated sarcomas are rarely identified in the intracranial region. A 23-year-old man was admitted with a chief complaint of headache. Initial magnetic resonance images showed signs of low-grade glioma in the frontal lobe. Stereotactic biopsy was performed, and a diagnosis of diffuse astrocytoma was confirmed. Three months later, the patient presented with a high-grade tumor as seen on imaging studies. He underwent total resection of the tumor and histopathological tests identified an undifferentiated sarcoma. The patient died eight months later due to massive tumor bleeding. To the best of our knowledge, this is the first report of undifferentiated sarcoma arising from low-grade glioma without any chemotherapy or radiotherapy.

Keyword

Intracranial undifferentiated sarcoma; Malignant fibrous histiocytoma; Low-Grade glioma; Malignant transformation; Stereotactic biopsy

MeSH Terms

Astrocytoma
Biopsy
Diagnosis
Drug Therapy
Frontal Lobe
Glioma*
Headache
Hemorrhage
Histiocytoma, Malignant Fibrous
Humans
Radiotherapy
Sarcoma*
Young Adult