J Korean Neurosurg Soc.  2015 Jun;57(6):428-431. 10.3340/jkns.2015.57.6.428.

Circulating Vascular Progenitor Cells in Moyamoya Disease

• Kang HS
• Wang KC
• Kim SK

• KMID: 2191249
• DOI: http://doi.org/10.3340/jkns.2015.57.6.428

Abstract

Various approaches have been attempted in translational moyamoya disease research. One promising material for modeling and treating this disease is vascular progenitor cells, which can be acquired and expanded from patient peripheral blood. These cells may provide a novel experimental model and enable us to obtain insights regarding moyamoya disease pathogenesis. We briefly present the recent accomplishments in regard to the studies of vascular progenitor cells in moyamoya disease.

Keyword

Moyamoya disease; Endothelial progenitor cell; Smooth muscle progenitor cell

MeSH Terms

Humans
Models, Theoretical
Moyamoya Disease*
Stem Cells*

Figure

• 

  Fig. 1 Vascular progenitor cells. Values on the y axis quantify the intensity of fluorescein isothiocyanate staining (FITC log), and on the x axis the values represent the number of cells counted. A : Early endothelial progenitor cells (EPCs), also called colony-forming units or cell clusters (×200). This cell cluster is composed of a central core of round cells that are surrounded by spindle shaped cells. B : Late EPCs, also known as endothelial outgrowth cells (×40). The cells are arranged in cobblestone-like formations. C : Smooth muscle progenitor cells (SPCs) (×40). These cells appear elon-gated and have a typical hill-and-valley appearance. D : Fluorescence-activated cell sorter analysis of the cells shown in C. The cells express smooth muscle myosin heavy chain (MHC) and calponin, which are smooth-muscle specific, with little expression of CD31 and fibroblast-specific protein 1 (FSP-1). αSMA : smooth muscle actin-alpha.

• 

  Fig. 2 Vascular progenitor cells. Values on the y axis quantify the intensity of fluorescein isothiocyanate staining (FITC log), and on the x axis the values represent the number of cells counted. A : Early endothelial progenitor cells (EPCs), also called colony-forming units or cell clusters (×200). This cell cluster is composed of a central core of round cells that are surrounded by spindle shaped cells. B : Late EPCs, also known as endothelial outgrowth cells (×40). The cells are arranged in cobblestone-like formations. C : Smooth muscle progenitor cells (SPCs) (×40). These cells appear elon-gated and have a typical hill-and-valley appearance. D : Fluorescence-activated cell sorter analysis of the cells shown in C. The cells express smooth muscle myosin heavy chain (MHC) and calponin, which are smooth-muscle specific, with little expression of CD31 and fibroblast-specific protein 1 (FSP-1). αSMA : smooth muscle actin-alpha.

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