J Korean Neurosurg Soc.  2004 Jun;35(6):639-642.

A Stereotactic Device for Gamma Knife Irradiation to Cell Lines

  • 1Department of Neurosurgery, Clinical Research Institute, Seoul National University College of Medicine, Seoul, Korea. hwnjung@snu.ac.kr


The purpose of this work is to build a well-plate holder for in vitro gamma knife irradiation to cell lines and to verify its validity. METHODS: A well-plate holder for gamma ray irradiation to cell lines using gamma knife was made of acrylonitrile. Inside the holder, a hexahedral space was excavated to hold well plates. The actual radiation dose to cell lines was obtained by comparing the relative dose of the holder with the gamma knife quality assurance standard phantom. All parameters necessary for cell line irradiation were calculated using the commercial software, Leksell Gamma Plan(R) v5.32. Dose distribution was drawn to six and ninety-six wells to search for optimal parameters for cell line irradiation. RESULTS: The dose rate at the center of the well-plate holder was 94+/-4% of the standard phantom and resulting absolute dose at the central area was 2.1+/-0.1Gy/min. The dose distributions of our phantom was the same as that of the standard phantom in qualitative comparison using an image analyzing software. Appropriate isodose lines which fit with the practical situation were obtained with the 18mm collimator of the Gamma knife. CONCLUSION: Our results show that a well-plate holder for gamma knife irradiation is confident and accurate. It can be used for the study of in vitro cellular effects by gamma knife irradiation in the future.


Gamma knife; Radiologi; phantoms; Radiation

MeSH Terms

Cell Line*
Gamma Rays
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