J Korean Med Assoc.  2009 Nov;52(11):1109-1114. 10.5124/jkma.2009.52.11.1109.

Drug Therapy of Dermatophytosis

Affiliations
  • 1Department of Dermatology, Konkuk University College of Medicine, Korea. 20070178@kuh.ac.kr, kjahn@kuh.ac.kr

Abstract

Dermatophytosis is a superficial infection caused by dermatophytes, a group of taxonomically related fungi. Dematophytes have the ability to form molecular attachments to keratin, use it as a source of nutrients, and then colonize keratinized tissues, including the stratum corneum of the epidermis, hair, nails, and the horny tissues of animals. For an effective treatment of dermatophytosis, antifungal agents must be able to reach dermatophytes in the keratin layer. The concentration of these drugs must also be maintained above therapeutic level for a sustained period of time. Newer oral antifungal agents, itraconazole, terbinafine, and fluconazole are widely used because of the improved therapeutic efficacy and an acceptable adverse effects profile. However, the drugs have different amount of the dose and period of administration, and the interaction of each individual agent is unique in each type of drugs. Therefore, an extreme caution must be exercised during the prescription of these antifungal agents.

Keyword

Dermatophytosis; Antifungal agents; Guideline

MeSH Terms

Animals
Antifungal Agents
Arthrodermataceae
Colon
Epidermis
Fluconazole
Fungi
Hair
Itraconazole
Keratins
Nails
Naphthalenes
Prescriptions
Tinea
Antifungal Agents
Fluconazole
Itraconazole
Keratins
Naphthalenes

Figure

  • Figure 1 A typical dermatophytic lesion and hyphae.


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