J Korean Med Assoc.  2009 Aug;52(8):779-786. 10.5124/jkma.2009.52.8.779.

Abnormal Uterine Bleeding in Adolescence

Affiliations
  • 1Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea. cyberpelvis@naver.com

Abstract

Abnormal uterine bleeding is a common clinical problem in adolescence but also a potentially difficult condition to treat. Furthermore, most diagnostic criteria and treatment algorithms were optimized for adults and not validated for adolescent population. Abnormal uterine bleeding may be associated with many conditions, including pregnancy, endocrine disorders, chronic diseases and congenital conditions. Using the menstrual cycle as an additional vital sign adds a powerful tool for the isolation of pathological conditions via the assessment of normal development. It is important for clinicians to have an understanding of bleeding patterns of adolescents, the ability to distinguish normal menstruation from abnormal one, and the skill to evaluate the young female patient appropriately. Routine evaluation should include a careful history, physical examination as indicated and permitted, and laboratory studies including a pregnancy test and a complete blood cell count. Quantifying the level of anemia and degree of bleeding along with managing expectations will provide basis for a more successful treatment plan that can almost always avoid surgical methods.

Keyword

Abnormal uterine bleeding; Dysfunctional uterine; Adolescence

MeSH Terms

Adolescent
Adult
Anemia
Blood Cell Count
Chronic Disease
Female
Hemorrhage
Humans
Menstrual Cycle
Menstruation
Physical Examination
Pregnancy
Pregnancy Tests
Uterine Hemorrhage
Vital Signs

Reference

1. Livingstone M, Fraser IS. Mechanisms of abnormal uterine bleeding. Hum Reprod Update. 2002. Jan-Feb. 8:60–67.
Article
2. Venturoli S, Porcu E, Fabbri R, Magrini O, Gammi L, Paradisi R, Flamigni C. Longitudinal evaluation of the different gonadotropin pulsatile patterns in anovulatory cycles of young girls. J Clin Endocrinol Metab. 1992. 04. 74:836–841.
3. Vihko R, Apter D. Endocrine characteristics of adolescent menstrual cycles: impact of early menarche. J Steroid Biochem. 1984. 01. 20:231–236.
Article
4. World Health Organization multicenter study on menstrual and ovulatory patterns in adolescent girls. II. Longitudinal study of menstrual patterns in the early postmenarcheal period, duration of bleeding episodes and menstrual cycles. World Health Organization Task Force on Adolescent Reproductive Health. J Adolesc Health Care. 1986. 07. 7:236–244.
5. Hickey M, Balen A. Menstrual disorders in adolescence: investigation and management. Hum Reprod Update. 2003. Sep-Oct. 9:493–504.
Article
6. Crosignani PG, Rubin B. Dysfunctional uterine bleeding. Hum Reprod. 1990. 07. 5:637–638.
Article
7. Fraser IS, Pearse C, Shearman RP, Elliott PM, McIlveen J, Markham R. Efficacy of mefenamic acid in patients with a complaint of menorrhagia. Obstet Gynecol. 1981. 11. 58:543–551.
Article
8. van Eijkeren MA, Scholten PC, Christiaens GC, Alsbach GP, Haspels AA. The alkaline hematin method for measuring menstrual blood loss- a modification and its clinical use in menorrhagia. Eur J Obstet Gynecol Reprod Biol. 1986. 09. 22:345–351.
Article
9. Liu Z, Doan QV, Blumenthal P, Dubois RW. A systematic review evaluating health-related quality of life, work impairment, and health-care costs and utilization in abnormal uterine bleeding. Value Health. 2007. May-Jun. 10:183–194.
Article
10. Friberg B, Orno AK, Lindgren A, Lethagen S. Bleeding disorders among young women: a population-based prevalence study. Acta Obstet Gynecol Scand. 2006. 85:200–206.
Article
11. Palomba S, Falbo A, Zullo F, Orio F Jr. Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev. 2009. 02. 30:1–50.
Article
12. Claessens EA, Cowell CA. Acute adolescent menorrhagia. Am J Obstet Gynecol. 1981. 02. 01. 13:9277–9280.
Article
13. Smith YR, Quint EH, Hertzberg RB. Menorrhagia in adolescents requiring hospitalization. J Pediatr Adolesc Gynecol. 1998. 02. 11:13–15.
Article
14. ACOG practice bulletin: management of anovulatory bleeding. Int J Gynaecol Obstet. 2001. 03. 72:263–271.
15. Kulp JL, Mwangi CN, Loveless M. Screening for coagulation disorders in adolescents with abnormal uterine bleeding. J Pediatr Adolesc Gynecol. 2008. 02. 21:27–30.
Article
16. Dijkhuizen FP, Brolmann HA, Potters AE, Bongers MY, Heinz AP. The accuracy of transvaginal ultrasonography in the diagnosis of endometrial abnormalities. Obstet Gynecol. 1996. 03. 87:345–349.
Article
17. Breitkopf DM, Frederickson RA, Snyder RR. Detection of benign endometrial masses by endometrial stripe measurement in premenopausal women. Obstet Gynecol. 2004. 07. 104:120–125.
Article
18. Farhi DC, Nosanchuk J, Silverberg SG. Endometrial adenocarcinoma in women under 25 years of age. Obstet Gynecol. 1986. 12. 68:741–745.
Article
19. Ferenczy A. Pathophysiology of endometrial bleeding. Maturitas. 2003. 05. 30. 45:1–14.
Article
20. Toth M, Patton DL, Esquenazi B, Shevchuk M, Thaler H, Divon M. Association between Chlamydia trachomatis and abnormal uterine bleeding. Am J Reprod Immunol. 2007. 05. 57:361–366.
Article
21. Quint EH, Smith YR. Abnormal uterine bleeding in adolescents. J Midwifery Womens Health. 2003. May-Jun. 48:186–191.
Article
22. Falcone T, Desjardins C, Bourque J, Granger L, Hemmings R, Quiros E. Dysfunctional uterine bleeding in adolescents. J Reprod Med. 1994. 10. 39:761–764.
Article
23. Janssen CA, Scholten PC, Heintz AP. A simple visual assessment technique to discriminate between menorrhagia and normal menstrual blood loss. Obstet Gynecol. 1995. 06. 85:977–982.
Article
24. Dubinsky T, Abu-Gazzeh Y, Stroehlein K. Role of transvaginal sonography and endometrial biopsy in the evaluation of dysfunctional uterine bleeding in premenopausal women. J Clin Ultrasound. 1998. Mar-Apr. 26:180–181.
Article
25. DeVore GR, Owens O, Kase N. Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding- a double-blind randomized control study. Obstet Gynecol. 1982. 03. 59:285–291.
26. Bowkley CW, Dubel GJ, Haas RA, Soares GM, Ahn SH. Uterine artery embolization for control of life-threatening hemorrhage at menarche: brief report. J Vasc Interv Radiol. 2007. 01. 18:127–131.
Article
27. Walker WJ, McDowell SJ. Pregnancy after uterine artery embolization for leiomyomata: a series of 56 completed pregnancies. Am J Obstet Gynecol. 2006. 11. 195:1266–1271.
Article
28. Gerschultz KL, Sucato GS, Hennon TR, Murray PJ, Gold MA. Extended cycling of combined hormonal contraceptives in adolescents: physician views and prescribing practices. J Adolesc Health. 2007. 02. 40:151–157.
Article
29. Bagwell MA, Thompson SJ, Addy CL, Coker AL, Baker ER. Primary infertility and oral contraceptive steroid use. Fertil Steril. 1995. 06. 63:1161–1166.
30. Willman EA, Collins WP, Clayton SG. Studies in the involvement of prostaglandins in uterine symptomatology and pathology. Br J Obstet Gynaecol. 1976. 05. 83:337–341.
Article
31. Smith SK, Abel MH, Kelly RW, Baird DT. Prostaglandin synthesis in the endometrium of women with ovular dysfunctional uterine bleeding. Br J Obstet Gynaecol. 1981. 04. 88:434–442.
Article
32. Lethaby A, Augood C, Duckitt K, Farquhar C. Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding. Cochrane Database Syst Rev. 2007. CD000400.
Article
33. Irvine GA, Cameron IT. Medical management of dysfunctional uterine bleeding. Baillieres Best Pract Res Clin Obstet Gynaecol. 1999. 06. 13:189–202.
Article
34. Rydin E, Lundberg PO. Letter: Tranexamic acid and intracranial thrombosis. Lancet. 1976. 07. 2:49.
35. Agnelli G, Gresele P, De Cunto M, Gallai V, Nenci GG. Tranexamic acid, intrauterine contraceptive devices and fatal cerebral arterial thrombosis. Case report. Br J Obstet Gynaecol. 1982. 08. 89:681–682.
Article
36. Andersch B, Milsom I, Rybo G. An objective evaluation of flurbiprofen and tranexamic acid in the treatment of idiopathic menorrhagia. Acta Obstet Gynecol Scand. 1988. 67:645–648.
Article
37. ACOG Committee Opinion No 392 December 2007 Intrauterine device and adolescents. Obstet Gynecol. 2007. 12. 110:1493–1495.
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