J Korean Androl Soc.  1991 Dec;9(2):81-85.

Chromosomal study in male infertility and recurrent abortion

Affiliations
  • 1Department of Urology, Je-il General Hospital, Seoul, Korea.
  • 2Cytogenetic Research Laboratory, Je-il General Hospital, Seoul, Korea.

Abstract

Among many factors known to influence spermatogenesis, chromosomal aberration is one of the best known. In order to determine the incidence and nature of chromosomal abnormalities associated with male infertility and recurrent abortion, we performed the cytogenetic study in the patients who visited Je-il General Hospital from January 1990 to November 1991. The results were as follows: 1. In 44 cases of azoospermia or severe oligospermia, sperm count < one million/ml, with small testicular volume less than eight cc, 30 patients (68.2%) with Klinefelter's syndrome and with 47XYY syndrome (2.3%) were found. 2. In 188 couples of recurrent abortion, abnormal karyotypes were found in 31(16.5%) couples. Chromosomal abnormalities were observed in 11(35%) husbands and 20(65%) wives. The chromosomal abnormalities of husband were inversion(5 cases), reciprocal translocation(3 cases), Robertsonian translocation(1 case), insertion(1 case) and deletion(1 case). 3. In addition, we detected polymorphic variants of chromosomes in 11(5.9%) subjects. In conclusion, these data suggested that cytogenetic study may be essential in the evaluation of male infertility and recurrent abortion.

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