J Korean Acad Rehabil Med.  2005 Aug;29(4):351-358.

Functional Status and Blood Level of IGF-1 and IGFBP-3 in Post-acute Stage Brain Diseases

• Choi DH
• Han TR
• Kim DY
• Lee SW
• Yoon KJ
• Kim JH
• Lim SH

Abstract

OBJECTIVE
To evaluate the blood level of IGF-1 (insulin-like growth factor-1) and IGFBP-3 (insulin-like growth factor binding protein-3) in patients with post-acute stage brain diseases, and to investigate the relationship between IGF-1/ IGFBP-3 blood level and functional status in patients with post-acute stage brain diseases. METHOD: Initial IGF-1/IGFBP-3 blood levels of 32 patients with post-acute stage brain disease were obtained and various functional indices, including modified Barthel index (MBI), functional ambulatory category (FAC), and Jebsen hand function test (JHFT), were assessed initially and at discharge.
RESULTS
The IGF-1 blood level was normal in 23 patients and decreased in 9. The IGFBP-3 blood level was normal in 20 patients and increased in 13. The initial IGF-1/IGFBP- 3 levels were associated with the change of MBI score during admission (p<0.05, r2=0.214/p<0.05, r2=0.213). There was a correlation between IGF-1/IGFBP-3 levels and JHFT score only on the unaffected side at discharge (p<0.05, r2=0.278). There was no relation between IGF-1/IGFBP-3 levels and the change of JHFT score on either side during admission.
CONCLUSION
Initial IGF-1/IGFBP-3 blood level check can be a useful method to anticipate functional improvement of patients with post-acute stage brain disease.

Keyword

IGF-1; IGFBP-3; Functional improvement

MeSH Terms

Brain Diseases*
Brain*
Hand
Humans
Insulin-Like Growth Factor Binding Protein 3*
Insulin-Like Growth Factor I*
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I