Intest Res.  2014 Jan;12(1):53-59. 10.5217/ir.2014.12.1.53.

Comparison of the Efficacy and Tolerability between Same-day Picosulfate and Split-dose Polyethylene Glycol Bowel Preparation for Afternoon Colonoscopy: A Prospective, Randomized, Investigator-blinded Trial

• Kang MS
• Kim TO
• Seo EH
• Jung DK
• Kim MS
• Heo NY
• Park JH
• Park SH
• Moon YS

• KMID: 2174338
• DOI: http://doi.org/10.5217/ir.2014.12.1.53

Abstract

BACKGROUND/AIMS
In the present study, we evaluated the efficacy and tolerability between same-day bowel preparation protocols using 2 sachets of Picosulfate and a 4 L split-dose polyethylene glycol (PEG) bowel preparation for afternoon colonoscopy.
METHODS
The study had a single-center, prospective, randomized, and investigator-blinded, non-inferiority design. We evaluated bowel preparation quality according to the Ottawa scale, patient tolerability, compliance, incidence of adverse events, sleep quality, and polyp/adenoma detection rate.
RESULTS
Among the 196 patients analyzed (mean age, 55.3 years; 50.3% men), 97 received the same-day regimen of 2 sachets of picosulfate (group A) and 99 received the 4 L split-dose PEG regimen (group B). The Ottawa score of the total colon was 4.05+/-1.56 in group A and 3.80+/-1.55 in group B (P=0.255). The proportion of patients having adequate bowel preparation in the same-day picosulfate group (61.5%) was slightly less than the 4 L PEG group (71.3%); however, the difference was not statistically significant (P=0.133). Tolerability of the group A regimen was superior to that of the group B regimen (P<0.000). The same-day picosulfate regimen was associated with fewer adverse events, such as abdominal bloating (P=0.037) and better sleep quality (P<0.000).
CONCLUSIONS
The same-day picosulfate regimen and the 4 L split-dose PEG regimen had similar efficacy in bowel preparation for afternoon colonoscopy. However, the same-day picosulfate regimen was easier to administer, produced fewer adverse events, and enabled better sleep quality.

Keyword

Colonoscopy; Sodium picosulfate; Polyethylene glycol

MeSH Terms

Colon
Colonoscopy*
Compliance
Humans
Incidence
Polyethylene Glycols*
Polyethylene*
Prospective Studies*
Polyethylene
Polyethylene Glycols

Figure

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  Fig. 1 Assignment of subjects into groups. Group A: 2 sachets of sodium picosulfate. Group B: 4 L of polyethylene glycol.

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  Fig. 2 Patient's ability to tolerate the bowel preparation. The tolerability of same-day picosulfate was superior to split-dose PEG (P<0.001).

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