J Gynecol Oncol.  2010 Dec;21(4):273-275. 10.3802/jgo.2010.21.4.273.

Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters

• Mousavi A
• Akhavan S

• KMID: 2173553
• DOI: http://doi.org/10.3802/jgo.2010.21.4.273

Abstract

Sarcoma botryoides (embryonal rhabdomyosarcoma) rarely arises in the uterine cervix. We report a case of a 14-year-old female with sarcoma botryoides who presented with prolonged vaginal bleeding and cervical polyp. The biopsy specimen confirmed sarcoma botryoides. The patient underwent radical surgery of the tumor and hysterectomy without adjuvant chemotherapy. The sister of the patient had died previously due to the same diagnosis at the age of 17. We achieved a satisfactory outcome in short-term period with radical surgery and hysterectomy. Presence of sarcoma botryoides of the cervix in two sisters in the family highlights the possible role of genetic factors in the development of sarcoma botryoides.

Keyword

Rhabdomyosarcoma; Sarcoma botryoides; Cervical cancer

MeSH Terms

Adolescent
Biopsy
Cervix Uteri
Chemotherapy, Adjuvant
Female
Humans
Hysterectomy
Polyps
Rhabdomyosarcoma
Sarcoma
Siblings
Uterine Cervical Neoplasms
Uterine Hemorrhage

Figure

• 

  Fig. 1 The tumor composed of pleomorphic spindle cells with dark pyknotic nuclei and a few round to oval cells with round nuclei and scant cytoplasm in abundant losse vascular myxoid stroma. The tumor cells detached from each other and forms stromal elements.

• 

  Fig. 2 The tumor composed of pleomorphic elongated spindle cells with some conspicious nucleoli with eosinophilic fibrillar cytoplasm. The spindle cells separated from each other by collagen fibers, with an irregular fascicular growth pattern.

Reference

1. Behtash N, Mousavi A, Tehranian A, Khanafshar N, Hanjani P. Embryonal rhabdomyosarcoma of the uterine cervix: case report and review of the literature. Gynecol Oncol. 2003. 91:452–455.

2. Gordon AN, Montag TW. Sarcoma botryoides of the cervix: excision followed by adjuvant chemotherapy for preservation of reproductive function. Gynecol Oncol. 1990. 36:119–124.

3. Bell J, Averette H, Davis J, Toledano S. Genital rhabdomyosarcoma: current management and review of the literature. Obstet Gynecol Surv. 1986. 41:257–263.

4. Atlante M, Dionisi B, Cioni M, Di Ruzza D, Sedati P, Mariani L. Sarcoma botryoides of the uterine cervix in a young woman: a case report. Eur J Gynaecol Oncol. 2000. 21:504–506.

5. Gruessner SE, Omwandho CO, Dreyer T, Blutters-Sawatzki R, Reiter A, Tinneberg HR, et al. Management of stage I cervical sarcoma botryoides in childhood and adolescence. Eur J Pediatr. 2004. 163:452–456.

6. Villella JA, Bogner PN, Jani-Sait SN, Block AM, Lele S. Rhabdomyosarcoma of the cervix in sisters with review of the literature. Gynecol Oncol. 2005. 99:742–748.

7. Daya DA, Scully RE. Sarcoma botryoides of the uterine cervix in young women: a clinicopathological study of 13 cases. Gynecol Oncol. 1988. 29:290–304.

8. Palazzo JP, Gibas Z, Dunton CJ, Talerman A. Cytogenetic study of botryoid rhabdomyosarcoma of the uterine cervix. Virchows Arch A Pathol Anat Histopathol. 1993. 422:87–91.

9. Zanetta G, Rota SM, Lissoni A, Chiari S, Bratina G, Mangioni C. Conservative treatment followed by chemotherapy with doxorubicin and ifosfamide for cervical sarcoma botryoides in young females. Br J Cancer. 1999. 80:403–406.

10. Potzsch C, Voigtlander T, Lubbert M. p53 Germline mutation in a patient with Li-Fraumeni Syndrome and three metachronous malignancies. J Cancer Res Clin Oncol. 2002. 128:456–460.