Chonnam Med J.  2000 Dec;36(4):329-335.

The Safety of Ibustrin (Indobufen) in the Patients Underwent Percutaneous Coronary Intervention

• Park JC
• Jeong MH
• Rhew JY
• Lee SH
• Kang KT
• Ahn YK
• Kwak SH
• Cho JG
• Park JC
• Kang JC

Abstract

Acute arterial occlusion and subacute thrombosis remain major clinical problems after percutaneous coronary intervention (PCI). A new anti-platelet agent, Indobufen, has anti-platelet activity by the reversible inhibition of cyclo-oxygenase, and adenosine diphosphate and adrenaline-induced aggregation. The efficacy and safety of Indobufen after PCI were investigated. Thirty patients underwent successful PCI between January 1999 and June 1999 at Chonnam National University Hospital, were divided into two groups, Group I (11 male, 4 female, 60+/- 8 years) receiving Indobufen after PCI and Group II (10 male, 5 female, 61+/-9 years) receiving aspirin, and clinical symptoms, blood and urine tests, and coagulation tests were compared between the groups. The clinical manifestations were 2 stable angina (SA), 7 unstable angina (USA), 4 acute myocardial infarction (AMI) and 2 old myocardial infarction (OMI) in Group I, and 3 SA, 7 USA, 4 AMI and 1 OMI in Group II (P=NS). Coronary angiographic findings of lesion characteristics, involved vessel number, location of lesion, Thrombolysis In Myocardial Infarction flow were not significantly different between two groups (P=NS). PCI using balloon angioplasty was performed in 5 in Group I and 4 in Group II, and stenting in 10 in Group I and 11 in Group II. Complete blood cell counts, urine analysis, liver and renal function tests, coagulation tests were not different between two groups during the follow-up period of 4 weeks after PCI. Subacute stent thrombosis developed in one of Group I, but the other complications did not occur in both groups. An anti-platelet agent, Indobufen, may be a safe and effective alternative in stead of aspirin after PCI.

Keyword

Aspipin; Indobufen; Plateltet; Percutaneous coronary intervention

MeSH Terms

Adenosine Diphosphate
Angina, Stable
Angina, Unstable
Angioplasty, Balloon
Aspirin
Blood Cell Count
Female
Follow-Up Studies
Humans
Jeollanam-do
Liver
Male
Myocardial Infarction
Percutaneous Coronary Intervention*
Prostaglandin-Endoperoxide Synthases
Stents
Thrombosis
Adenosine Diphosphate
Aspirin
Prostaglandin-Endoperoxide Synthases