Chonnam Med J.
2001 Dec;37(4):431-435.
A Case of Refractory Gastrointestinal Stromal Tumor Rapidly Responded with STI571 (Glivec(R))
- Affiliations
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- 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
- 2Chonnam National University, Research Institute of Medical Sciences, Gwangju, Korea.
Abstract
- Gastrointestinal stromal tumors (GIST) are a group of neoplasms that arise from mesenchymal cells of the gastrointestinal tract. Recently, it is known that STI571 selectively inhibits the enzymatic activity of several tyrosine kinases, such as c-kit in GIST, resulting in the trials of STI571 therapy in GIST. A 45-year-old man who was surgically treated for GIST in 2 years ago relapsed on liver and abdomen. Despite 2 cycles of combination chemotherapy, the size of mass was continuously increased to 58.2 cm2 (liver) and 71.8 cm2 (abdomen) in follow-up CT scan. After treatment with oral STI571 400 mg once daily, a rapid partial response was shown on liver (36.9 cm2 after 2 weeks, 23.9 cm2 after 9 weeks) and on abdomen (48.9 cm2 after 2weeks, 31.9 cm2 after 9 weeks).
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