Hanyang Med Rev.  2013 Aug;33(3):165-169. 10.7599/hmr.2013.33.3.165.

Current Status of Basic Research in Orthopaedics

• Im GI

• KMID: 2168262
• DOI: http://doi.org/10.7599/hmr.2013.33.3.165

Abstract

Orthopaedic medicine has developed and benefited from the advancement of related basic science. Current technologies such as joint replacement and internal fixation of fractures started from research on biocompatible biomaterials and on the understanding of body biomechanics. As ongoing research on life science may dramatically change the appearance of future orthopaedic medicine, it is very important to keep abreast with recent trends of related basic science. This review introduces the realm of basic sciences related to orthopaedic medicine along with comments on future perspectives.

Keyword

Orthopedics; Biomedical Research; Review

MeSH Terms

Biocompatible Materials
Biological Science Disciplines
Biomechanics
Joints
Orthopedics
Biocompatible Materials

Reference

1. The Korean Orthopaedic Association. Orthopaedics. 6th ed. Seoul: The Korean Orthopaedic Association;2006. p. 3–4. p. 62–67.

2. The Korean Society for Biomaterials. Biomaterials. Seoul: Freedom Academy Publishing;2009. p. 10–181.

3. Hatze H. Letter: The meaning of the term "biomechanics". J Biomech. 1974; 7:189–190.

4. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994; 331:889–895.

5. Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991; 9:641–650.

6. Im GI, Kim DY, Shin JH, Hyun CW, Cho WH. Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow. J Bone Joint Surg Br. 2001; 83:289–294.

7. Im GI, Shin YW, Lee KB. Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells? Osteoarthritis Cartilage. 2005; 13:845–853.

8. Im GI, Jung NH, Tae SK. Chondrogenic differentiation of mesenchymal stem cells isolated from patients in late adulthood: the optimal conditions of growth factors. Tissue Eng. 2006; 12:527–536.

9. Kim HJ, Kim YJ, Im GI. Is continuous treatment with transforming growth factor-beta necessary to induce chondrogenic differentiation in mesenchymal stem cells? Cells Tissues Organs. 2009; 190:1–10.

10. Kim HJ, Im GI. Chondrogenic differentiation of adipose tissue-derived mesenchymal stem cells: greater doses of growth factor are necessary. J Orthop Res. 2009; 27:612–619.

11. Kim HJ, Im GI. Combination of transforming growth factor-beta2 and bone morphogenetic protein 7 enhances chondrogenesis from adipose tissue-derived mesenchymal stem cells. Tissue Eng Part A. 2009; 15:1543–1551.

12. Lee JS, Im GI. Influence of chondrocytes on the chondrogenic differentiation of adipose stem cells. Tissue Eng Part A. 2010; 16:3569–3577.

13. Kim YJ, Kim HJ, Im GI. PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs. Biochem Biophys Res Commun. 2008; 373:104–108.

14. Kim HJ, Im GI. The effects of ERK1/2 inhibitor on the chondrogenesis of bone marrow- and adipose tissue-derived multipotent mesenchymal stromal cells. Tissue Eng Part A. 2010; 16:851–860.

15. Im GI, Quan Z. The effects of Wnt inhibitors on the chondrogenesis of human mesenchymal stem cells. Tissue Eng Part A. 2010; 16:2405–2413.

16. Im GI, Lee JM, Kim HJ. Wnt inhibitors enhance chondrogenesis of human mesenchymal stem cells in a long-term pellet culture. Biotechnol Lett. 2011; 33:1061–1068.

17. Im GI, Kim HJ. Electroporation-mediated gene transfer of SOX trio to enhance chondrogenesis in adipose stem cells. Osteoarthritis Cartilage. 2011; 19:449–457.

18. Kim HJ, Im GI. Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem Cells Dev. 2011; 20:2103–2114.

19. Lee JM, Im GI. SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat. Biomaterials. 2012; 33:2016–2024.

20. Im GI, Kim HJ, Lee JH. Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes. Biomaterials. 2011; 32:4385–4392.

21. Lee JS, Lee JM, Im GI. Electroporation-mediated transfer of Runx2 and Osterix genes to enhance osteogenesis of adipose stem cells. Biomaterials. 2011; 32:760–768.

22. Kim KI, Park YS, Im GI. Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage. J Bone Miner Res. 2013; 28:1050–1060.