Cancer Res Treat.  2010 Mar;42(1):53-56.

A Case of Synchronous Double Primary Cancer of the Penis and Urinary Bladder

Affiliations
  • 1Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea. lee982023@eulji.ac.kr
  • 2Department of Pathology, Eulji University School of Medicine, Daejeon, Korea.
  • 3Department of Radiation Oncology, Eulji University School of Medicine, Daejeon, Korea.
  • 4Department of Urology, Eulji University School of Medicine, Daejeon, Korea.

Abstract

Multiple primary cancers are the occurrence of more than two cancers of different origin in an individual. Penile cancer is a rare disease, and finding it combined with other cancers is even rarer. A 64-year-old man with a painful penile mass was referred to us from a primary urological clinic. We performed a biopsy of the penile mass and the histology revealed a well-differentiated squamous cell carcinoma. Abdominal computed tomography showed a localized bladder tumor with inguinal lymphadenopathy. The patient underwent a partial penectomy, transurethral resection of the bladder tumor and inguinal lymph node dissection. The histology of the bladder tumor was high-grade papillary carcinoma, and that of the lymph node was squamous cell carcinoma. The penile and bladder tumors were in stage II (T1N1M0) and stage I (T1N0M0), respectively. We successfully treated the patient with adjuvant radiotherapy and systemic chemotherapy.

Keyword

Neoplasms; Multiple primary; Urinary bladder neoplasms; Penile neoplasms

MeSH Terms

Biopsy
Carcinoma, Papillary
Carcinoma, Squamous Cell
Humans
Lymph Node Excision
Lymph Nodes
Lymphatic Diseases
Male
Middle Aged
Penile Neoplasms
Radiotherapy, Adjuvant
Rare Diseases
Urinary Bladder
Urinary Bladder Neoplasms

Figure

  • Fig. 1 The pathologic features of the penile tumor (H&E stain, ×200). The microphotograph showed an invasive squamous cell carcinoma with well-differentiated mature squamous cells and abundant keratin pearls and occasional well-developed intercellular bridges.

  • Fig. 2 (A) The abdominal CT showed an approximately 1 cm sized enhancing luminal protruding polypoid mass on the left posterior wall of the urinary bladder. (B) The abdominal CT showed a 2.2 cm enlarged lymph node with a tendency for focal infiltration in the left inguinal area.

  • Fig. 3 (A) The pathologic features of the bladder tumor (H&E stain, ×200). The microphotograph showed an invasive urothelial carcinoma with more nuclear pleomorphism, anaplasia and many mitotic figures. (B) The pathologic features of the left inguinal lymph node (H&E stain, ×100). The microphotograph showed a metastatic squamous cell carcinoma with less differentiation and more nuclear pleomorphism and mitotic activity.


Reference

1. Billroth T. General surgical pathology and therapeutics in 51 Vorlesungen: a textbook for students and physicians in fifty-one lectures. 1889. 14th ed. Berlin, DE: G. Rerimer.
2. Warren S, Gates O. Multiple primary malignant tumors; Surgery of literature and statistical study. Am J Cancer. 1932; 16:1358–1414.
3. Wegner HE. Multiple primary cancers in urologic patients: Audit of 19-year experience in Berlin and review of the literature. Urology. 1992; 39:231–236. PMID: 1546416.
Article
4. Lee C, Lee ES, Choi H, Koh SK, Lee JM, Chai SE, et al. Incidence estimation of genitourinary cancer in Korea. J Korean Med Sci. 1992; 7:154–161. PMID: 1524728.
Article
5. Barnholtz-Sloan JS, Maldonado JL, Pow-sang J, Giuliano AR. Incidence trends in primary malignant penile cancer. Urol Oncol. 2007; 25:361–367. PMID: 17826651.
Article
6. Kim WJ, Chung JI, Hong JH, Kim CS, Jung SI, Yoon DK. Epidemiological study for urologic cancer in Korea (1998-2002). Korean J Urol. 2004; 45:1081–1088.
7. Kakizaki H, Abe Y, Sugano O, Kato H. A hundred cases of multiple primary neoplasms in association with genitourinary cancer. Nippon Hinyokika Gakkai Zasshi. 1992; 83:1841–1846. PMID: 1479754.
Article
8. Kim CK, Chang JW. Multiple primary malignant tumors. J Korean Surg Soc. 1970; 12:63–71.
9. Koo DJ, Yun DS, Lee JJ, Park CJ. Clinical analysis of 65 multiple primary cancer cases. J Korean Surg Soc. 1999; 56:137–142.
10. Kang HJ, Choi S, Kim JC, Rhew HY. Multiple primary malignant neoplasms in genitourinary tract. Korean J Urol. 1994; 35:1265–1270.
11. Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasm. II. Tumors of different tissues or organs. Cancer. 1961; 14:231–237. PMID: 13771653.
12. Matzkin H, Braf Z. Multiple primary malignant neoplasms in the genitourinary tract: occurrence and etiology. J Urol. 1989; 142:1–12. PMID: 2659818.
Article
13. Dillner J, von Krogh G, Horenblas S, Meijer CJ. Etiology of squamous cell carcinoma of the penis. Scand J Urol Nephrol Suppl. 2000; 205:189–193. PMID: 11144896.
Article
14. Weinberg DM, Ross RK, Mack TM, Paganini-Hill A, Henderson BE. Bladder cancer etiology. A different perspective. Cancer. 1983; 51:675–680. PMID: 6821840.
Article
15. Martins FE, Rodrigues RN, Lopes TM. Organ-preserving surgery for penile carcinoma. Adv Urol. 2008; 634216. PMID: 19009032.
Article
Full Text Links
  • CRT
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr