Ann Dermatol.  2015 Dec;27(6):782-784. 10.5021/ad.2015.27.6.782.

Dysplastic Nevus with Eruptive Melanocytic Lesions That Developed during Nilotinib Therapy for Chronic Myeloid Leukemia

  • 1Department of Dermatology, The Catholic University of Korea, College of Medicine, Seoul, Korea.


No abstract available.

MeSH Terms

Dysplastic Nevus Syndrome*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*


  • Fig. 1 Dermoscopic picture showing structureless pigmentation with asymmetric and irregular and fuzzy borders, and several blackish globules.

  • Fig. 2 (A) Histopathological picture of the benign melanocytic lesion showing slightly elongated, clubbed rete ridges and intermittently distributed single melanocytes at the tip and side of the rete ridges. Lesional melanocytes did not show dysplasia (H&E, ×100; left inset: ×400; right inset: clinical picture). (B) Histopathological picture of the atypical pigmented lesion showing elongated, fused rete ridges and contiguously distributed single melanocytes and a few small nests at the dermal-epidermal junction. In addition, eosinophilic fibroplasias and mild perivascular infiltrate were observed. Lesional melanocytes were observed to have moderately enlarged nuclei compared with most normal melanocytes and slightly irregular, hyperchromatic nuclei on the high-power field (×100; left inset: ×400; right inset: clinical picture). (C) Melan-A immunoreactivity of contiguously distributed melanocytes (×100). (D) HMB45 immunoreactivity of contiguously distributed melanocytes (×100).


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