Ann Dermatol.  2015 Dec;27(6):688-693. 10.5021/ad.2015.27.6.688.

High-Intensity Focused Ultrasound for the Treatment of Wrinkles and Skin Laxity in Seven Different Facial Areas

  • 1Department of Dermatology, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, Korea.
  • 2Toomyung Dermatology, Seoul, Korea.


High-intensity focused ultrasound (HIFU) treatment has recently emerged in response to the increasing demand for noninvasive procedures for skin lifting and tightening.
This study was aimed at evaluating the clinical efficacy of and patient satisfaction with HIFU treatment for wrinkles and laxity in seven different areas of the face in Asian skin.
Twenty Korean patients with facial wrinkle and laxity were analyzed after a single session of HIFU treatment. Two independent, blinded clinicians evaluated the clinical improvement in seven areas of the face by comparison of standardized photographs obtained before, and at 3 and 6 months after treatment. Assessment of subjective satisfaction and adverse effects of treatment were done by using questionnaires.
The physicians' evaluation and patients' satisfaction with the clinical effects of HIFU in each area were similar regardless of the number of treatment shots. The jawline, cheek, and perioral areas were the sites where HIFU was most effective, in decreasing order. The adverse effects included erythema and swelling in six cases, and purpura and bruising in two cases. However, the adverse effects were mild and transient.
HIFU could be a safe, effective, and noninvasive procedure that can be used to improve facial wrinkles and skin laxity in Asian skin. It is particularly effective for clinical improvement in the jawline, cheek, and perioral areas.


High-intensity focused ultrasound; Laxity; Wrinkle

MeSH Terms

Asian Continental Ancestry Group
Patient Satisfaction


  • Fig. 1 Clinical photographs showing before (A, D), 3 months (B, D), and 6 months (C, F) after high-intensity focused ultrasound treatment.

  • Fig. 2 Physicians' evaluation score for the treatment areas. 0: none, 1: mild, 2: mild/moderate, 3: moderate, 4: severe.

  • Fig. 3 Patients' satisfaction score for the treatment areas. 1: not satisfied; 2: somewhat satisfied; 3: satisfied; 4: very satisfied; 5: extremely satisfied.

  • Fig. 4 Results of the questionnaire: the most improved area (A), the side effects (B), and the willingness (C) to continue and recommend Ulthera™.


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