Ann Dermatol.  2011 Oct;23(Suppl 2):S147-S150. 10.5021/ad.2011.23.S2.S147.

Large Dermal Non Neural Granular Cell Tumor on the Surgical Wound Site

Affiliations
  • 1Department of Dermatology, College of Medicine, Dankook University, Cheonan, Korea. 4exodus@hanmail.net

Abstract

Granular cell tumors (GCTs) can be divided into neural type with S-100 reactivity and non-neural type without that. The latter has not been widely recognized and there are only fewer reports available when compared to conventional GCT. A 65-year-old man was presented with the presence of a painless mass on his back. The mass had developed into a small nodule on the scar developed because of previous surgery carried out 2 years ago. The tumor consisted of large, polygonal cells comprising of an enormous number of faintly eosinophilic small granules in the cytoplasm. The cytoplasmic granules were stained positively for periodic acid-Schiff stain. Immunohistochemical stains for S-100 protein and neuron-specific enolase were found to be negative. Herein, we report the appearance of a very rare case of non neural GCT developed on the surgical scar in support with relevant literature reviews.

Keyword

Granular cell tumors; Scar; S-100

MeSH Terms

Aged
Cicatrix
Coloring Agents
Cytoplasm
Cytoplasmic Granules
Eosinophils
Granular Cell Tumor
Humans
Phosphopyruvate Hydratase
S100 Proteins
Coloring Agents
Phosphopyruvate Hydratase
S100 Proteins

Figure

  • Fig. 1 (A) Solitary hard, fixed dermal mass on the left lateral chest wall. (B) Computed tomography scan revealing the presence of an oval mass with dimensions of 3.6×2.5 cm in the subcutaneous layer adjacent to intercostal muscle.

  • Fig. 2 (A) Diffuse infiltration of monomorphic tumor cells on the dermis (H&E, ×40). (B) Large, polygonal tumor cells with abundant faintly eosinophilic granular cytoplasm (H&E, ×400).

  • Fig. 3 (A) The cytoplasmic granules showing positive stain with periodic acid-Schiff (×400). (B) Immunohistochemical stains revealed positivity for CD68 (×400). (C, D) Stains for S-100 protein, neuron-specific enolase were negative (C: S-100, ×40, D: NSE, ×200).


Cited by  1 articles

Congenital Non-Neural Granular Cell Tumor Mimicking Nevus Lipomatosus Superficialis
Jun Yeong Park, Won Joo Kwon, Bok Won Park, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
Ann Dermatol. 2017;29(6):776-778.    doi: 10.5021/ad.2017.29.6.776.


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