Ann Dermatol.  2011 Sep;23(Suppl 1):S1-S3. 10.5021/ad.2011.23.S1.S1.

Fluconazole Induced Fixed Drug Eruption

• Kim CY
• Kim JG
• Oh CW

• KMID: 2156738
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S1

Abstract

We report on a rare case of fluconazole induced fixed drug eruption in a 62-year old female patient. She was referred to our department for multiple erythematous itchy maculopatches on the face, neck, both upper arms, and trunk area, which had occurred over the previous 6 months. Her attending physician prescribed fluconazole for treatment of onychomycosis. Patch test and oral provocation were performed. The patch test showed a negative result; however, the result for oral provocation was positive, confirming this as a rare case of fluconazole induced fixed drug eruption. To the best of our knowledge, this is the first reported case in Korean dermatologic literature.

Keyword

Drug eruption; Fluconazole

MeSH Terms

Arm
Drug Eruptions
Female
Fluconazole
Humans
Neck
Onychomycosis
Patch Tests
Fluconazole

Figure

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  Fig. 1 Oval, swollen, brownish pigmented patches on the ant. Chest (A: Day 3 of eruption, B: 30 minutes after oral provocation).

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  Fig. 2 (A) Skin biopsy specimen shows basal vacuolated and necrotic keratinocytes with dermal inflammatory cell infiltration and pigmentary incontinence (H&E, ×100). (B) Necrotic keratinocytes and basal vacuolation are observed and dermal inflammtory cells are dominant mononuclear cells (H&E, ×200).

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