Ann Dermatol.  2008 Sep;20(3):153-156. 10.5021/ad.2008.20.3.153.

Combined Mastocytoma-hemangioma in a Patient with Urticaria Pigmentosa

  • 1Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea.


A patient with long-standing urticaria pigmentosa presented with a pea-sized reddish to purplish papule on the posterior part of the right ear. Histopathologic examination revealed numerous dilated vascular structures in the upper dermis and mast cell infiltrations throughout the whole dermis, consistent with combined mastocytoma-hemangioma. The mast cells were strongly positive with Giemsa stain.


Hemangioma; Mastocytoma

MeSH Terms

Azure Stains
Mast Cells
Urticaria Pigmentosa
Azure Stains


  • Fig. 1 Biopsy specimen of the skin lesion of urticaria pigmentosa before hemangioma developed. Hyperpigmented basal layer and scattered cuboidal mast cells in the dermis, especially at the perivascular area (Hematoxylin-Eosin stain; original magnification, ×400).

  • Fig. 2 A 0.5×0.7 cm sized reddish to purplish soft papule on the posterior part of the right ear.

  • Fig. 3 Excisional biopsy specimens of the skin lesion showed (A) flattened rete ridge without basal hyperpigmentation, multiple dilated endothelial cell-lined vascular structures containing red blood cells in the upper dermis, and densely infiltrated mast cells throughout the whole dermis including the intercapillary stroma (Hematoxylin-Eosin staining; original magnification, ×100). (B) At the higher magnification view, the infiltrated mast cells were shown as round to cuboidal cytoplasm with central ovoid nuclei (Hematoxylin-eosin stain; original magnification, ×400).

  • Fig. 4 Mast cells with abundant fine purple metachromatic cytoplasmic granules were observed (Giemsa stain; original magnification, ×400).


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