Korean J Anesthesiol.  2000 Jun;38(6):1036-1041. 10.4097/kjae.2000.38.6.1036.

The Comparison of Antiemetic Effects of Metoclopramide, Granisetron and Ondansetron in Middle Ear Surgery

• Yeu W
• Seo CM
• Jung SH
• Park SS
• Hong JG
• Park JW

• KMID: 2155256
• DOI: http://doi.org/10.4097/kjae.2000.38.6.1036

Abstract

BACKGROUND: Postoperative nausea and vomiting (PONV) is a distressing adverse effect of anesthesia. This study was designed to evaluate antiemetic effects of metoclopramide, ondansetron and granisetron in middle ear surgery.
METHODS
We compared the antiemetic activity of prophylactic administration of metoclopramide, ondansetron and granisetron in 103 patients undergoing middle ear surgery (tympanomastoidectomy and tympanoplasty). All Study drugs were given as a short intravenous infusion 30 minutes before the end of anesthesia. The incidence of PONV were assessed by direct questioning of patients at 6, 12, 24 and 48 hr after recovery from anesthesia.
RESULTS
For the first 6 hr recovery period after surgery, the percentages of emesis in patients were 46.7%, 16%, 12% and 16% in the control, metoclopramide, ondansetron and granisetron groups respectively. After 6 hr, the percentage of emesis in patients significantly decreased in the control, ondansetron and granisetron groups when compared with the first 6 hr, but in the metoclopramide group there was no changes after 6 hr.
CONCLUSIONS
The antiemetic drugs, metoclopramide, ondansetron and granisetron, were all effective in controling PONV in middle ear surgery.

Keyword

Vomiting: 5-HT3 antagonist; nausea; postoperative

MeSH Terms

Anesthesia
Antiemetics*
Ear, Middle*
Granisetron*
Humans
Incidence
Infusions, Intravenous
Metoclopramide*
Ondansetron*
Postoperative Nausea and Vomiting
Vomiting
Antiemetics
Granisetron
Metoclopramide
Ondansetron