Korean J Urol.  1990 Feb;31(1):14-22.

Effects of M-VAC(Methotrexate, Vinblastine, Doxorubicin and Cisplatin) Regimen on Experimental Animal: Histopathological Study

• Kim SJ
• Kim WJ
• Kim YK

Abstract

Histopathologic study was performed to observe the effects of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin), widely used for advanced bladder cancer and its metastatic lesion, on the visceral organs of the experimental animal. M-VAC was used intraperitoneally throughout the study and the following results were obtained : 1. There were severe adhesions of visceral organs in all of experimental groups, compared with the control group. 2. Compared with the control group(15.0%), significant increase of incidence in renal cystic changes in experimental group(89.6%) was observed. The lesions were similar to polycystic kidney type I and considered to be irreversible. Therefore, ultrasonography of the kidney during the M-VAC regimen may be clinically worthwhile. 3. Portal triaditis ( 27.5% ) and fatty metamorphosis of the liver(24.1%) were observed significantly in the experimental group but they were limited, localized changes and thought to be reversible. Deterioration in hepatic function may not be seriously considered.

Keyword

M-VAC; bladder cancer

MeSH Terms

Animals*
Doxorubicin*
Incidence
Kidney
Polycystic Kidney Diseases
Ultrasonography
Urinary Bladder Neoplasms
Vinblastine*
Doxorubicin
Vinblastine