Blood Res.  2015 Dec;50(4):264-267. 10.5045/br.2015.50.4.264.

Sickle cell-beta thalassemia with concomitant hemophilia A: a rare presentation

Affiliations
  • 1Department of Hematology, Institute of Liver and Biliary Sciences, New Delhi, India. dhimandrpratibha@yahoo.com
  • 2Department of Pathology, ESI Hospital, New Delhi, India.

Abstract

No abstract available.


MeSH Terms

Hemophilia A*
Thalassemia*

Figure

  • Fig. 1 Photomicrograph of peripheral blood film showing anisopoikilocytosis with sickle-shaped cells, target cells, and nucleated RBCs.

  • Fig. 2 Hb electrophoresis at alkaline pH showing a faint band in the A2 region, a prominent band in the SDG region, and HbF.


Reference

1. Mukherjee MB, Nadkarni AH, Gorakshakar AC, Ghosh K, Mohanty D, Colah RB. Clinical, hematologic and molecular variability of sickle cell-β thalassemia in western India. Indian J Hum Genet. 2010; 16:154–158. PMID: 21206704.
Article
2. Mohanty D, Colah RB, Gorakshakar AC, et al. Prevalence of β-thalassemia and other haemoglobinopathies in six cities in India: a multicentre study. J Community Genet. 2013; 4:33–42. PMID: 23086467.
Article
3. Silvestroni E, Bianco I. Microdrepanocito-anemia in un soggetto di razza Bianca. Boll A Accad Med Roma. 1944; 70:347.
4. Serjeant GR, Ashcroft MT, Serjeant BE, Milner PF. The clinical features of sickle-cell-thalassaemia in Jamaica. Br J Haematol. 1973; 24:19–30. PMID: 4715134.
5. Mosher DF. Disorders of blood coagulation. In : Wyangaarden JB, Smith LH, Bennett JC, editors. Cecil textbook of medicine. Philadelphia, PA: WB Saunders;1992. p. 1004–1006.
6. Escuriola Ettingshausen C, Halimeh S, Kurnik K, et al. Symptomatic onset of severe hemophilia A in childhood is dependent on the presence of prothrombotic risk factors. Thromb Haemost. 2001; 85:218–220. PMID: 11246535.
Article
7. Weatherall DJ, Clegg JB. The thalassaemia syndromes. 4th ed. Oxford, UK: Blackwell Science Ltd;2001. p. 395.
8. Kulozik AE, Bail S, Kar BC, Serjeant BE, Serjeant GE. Sickle cell-beta+ thalassaemia in Orissa State, India. Br J Haematol. 1991; 77:215–220. PMID: 2004023.
9. Gregg-Smith SJ, Pattison RM, Dodd CA, Giangrande PL, Duthie RB. Septic arthritis in haemophilia. J Bone Joint Surg Br. 1993; 75:368–370. PMID: 8098712.
Article
10. Hoyer LW. Hemophilia A. N Engl J Med. 1994; 330:38–47. PMID: 8259143.
Article
11. Colah RB, Shetty SD, Surve RR, et al. Prenatal diagnosis in a family at risk for beta-thalassemia and hemophilia A: an uncommon association. Hemoglobin. 2004; 28:343–346. PMID: 15658191.
12. Capra R, Mattioli F, Kalman B, Marcianò N, Berenzi A, Benetti A. Two sisters with multiple sclerosis, lamellar ichthyosis, beta thalassaemia minor and a deficiency of factor VIII. J Neurol. 1993; 240:336–338. PMID: 8336172.
Article
13. Giannini E, Fasoli A, Botta F, Testa R. Wilson's disease with concomitant beta thalassaemia and factor V deficiency. Ital J Gastroenterol Hepatol. 1998; 30:633–635. PMID: 10076789.
14. Eldor A, Rachmilewitz EA. The hypercoagulable state in thalassemia. Blood. 2002; 99:36–43. PMID: 11756150.
Article
15. Ataga KI. Hypercoagulability and thrombotic complications in hemolytic anemias. Haematologica. 2009; 94:1481–1484. PMID: 19880774.
Article
Full Text Links
  • BR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr