J Korean Ophthalmol Soc.  2005 Dec;46(12):2086-2090.

Primary Cutaneous Anaplastic Large Cell Lymphoma of the Lower Lid

• Kim MR
• Chi JY
• Ko YH
• Kim YD

Abstract

PURPOSE
Primary cutaneous anaplastic large cell lymphoma is rarely encountered in the lower eyelids. We report a patient with primary cutaneous anaplastic large cell lymphoma arising from the lower eyelid. METHODS: A 39-year-old man presented with a relatively fast growing mass on the center of his left lower eyelid for one month. The mass did not respond to local injection of triamcinolone at a local clinic. The lesion appeared as a solitary reddish nodule with ulceration, was non-tender, round, crusted, and measured 13 mm x 11 mm x 5 mm. Well- developed superficial vessels were found on the surface of the nodule. An incisional biopsy was performed.
RESULTS
Histologic examination revealed that the bulk of the infiltrate was in the papillary and reticular dermis. Tumor cells had abundant, well-defined cytoplasm and pleomorphic nuclei with multiple nucleoli. The majority of the neoplastic cells showed immunoreactivity for CD 30 (Ki-1) along the cell membrane. A histopathological diagnosis of primary cutaneous anaplastic large cell lymphoma was made.
CONCLUSIONS
Most cases of primary cutaneous anaplastic large cell lymphoma arise from the body and extremities. However, since primary cutaneous anaplastic large cell lymphoma may occur in the eyelid, it should be differentiated from nodular and relatively fast growing inflammatory tumors despite local steroid treatment.

Keyword

Cutaneous anaplastic large cell lymphoma; Eyelid tumor; Inflammatory lesion

MeSH Terms

Adult
Biopsy
Cell Membrane
Cytoplasm
Dermis
Diagnosis
Extremities
Eyelids
Humans
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
Triamcinolone
Ulcer
Triamcinolone